Overexpression of Brain-Derived Neurotrophic Factor ... - eNeuro

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Jan 5, 2017 - Ganglion Cells Following Optic Nerve Crush in Mice ..... were scattered across the retina within the ganglion cell layer (GCL, Fig. 1D, left).
This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version.

Research Article: New Research | Disorders of the Nervous System

Overexpression of Brain-Derived Neurotrophic Factor Protects Large Retinal Ganglion Cells Following Optic Nerve Crush in Mice BDNF protects large RGCs from optic nerve injury Liang Feng1,2, Zhen Puyang1,3,4, Hui Chen1,2, Peiji Liang4, John B. Troy3 and Xiaorong Liu1,2 1

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611

2

Department of Neurobiology, Weinberg College of Arts and Sciences, Northwestern University, Evanston, Illinois 60208 3

Department of Biomedical Engineering, Robert R. McCormick School of Engineering and Applied Science, Northwestern University, Evanston, Illinois 60208 4

School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-chuan Road, Shanghai 200240, China DOI: 10.1523/ENEURO.0331-16.2016 Received: 3 November 2016 Revised: 21 December 2016 Accepted: 28 December 2016 Published: 5 January 2017

Author contributions: L.F., Z.P. and X.L. conceived and designed the experiments; P.L., J.B.T., and X.L. provided materials; L.F., Z.P., and H.C. performed the experiments and data analysis; L.F., Z.P. and X.L. prepared the Figures; L.F., Z.P. and X.L. wrote the manuscript, L.F., Z.P., H.C., P.L., J.B.T., and X.L. edited and approved the manuscript. Funding: HHS | NIH | National Eye Institute (NEI) 100000053 R01EY026286

Funding: BrightFocus Foundation 100006312

Funding: Research to Prevent Blindness (RPB) 100001818

Funding: National Natural Science Foundation of China (NSFC) 501100001809 31471054

The authors declare no competing financial interests. L.F. and Z.P. contributed equally to this work. Corresponding author: Xiaorong Liu, 847-467-0529; Hogan 2-160, 2205 Tech Drive, Northwestern University, Evanston, IL, 60208. [email protected] Cite as: eNeuro 2017; 10.1523/ENEURO.0331-16.2016 Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Copyright © 2017 the authors

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