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S8 Fig. Box-whisker plots of the detected metabolites of central carbon metabolism in P. putida DOT-T1E, DOT-T1E-PS28 and DOT-T1E-18. Dashed lines separate different concentration levels of propranolol and solid line separates different strains. The label is constructed in a format of “Aac”, “A” represents strains, varies from A to C: A = P. putida DOT-T1E; B = P. putida DOT-T1E-PS28 and C = P. putida DOT-T1E-18. “a” represents 4 different concentration levels, varies from 0 to 3: 0 = control; 1 = -1 -1 -1 0.2 mg mL ; 2 = 0.4 mg mL and 3 = 0.6 mg mL propranolol. “c” represents time points, 1 = T0 (0 min); 2 = T1 (10 min) and 3 = T2 (1 h). Such plots give a comprehensive view of how the concentration levels of the metabolite changing under each unique combination of the factors (strains, dosage of propranolol and time). Variables 14 (alanine), Variables 20 (valine), Variables 29 (leucine), and Variables 34 (isoleucine).
