Pathophysiology 451

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In absence of NRG-1, Ang II induced arterial hypertension, concentric LV hy- pertrophy, interstitial myocardial fibrosis, and LV diastolic failure (increased slope.

Pathophysiology

dent predictor of the nondipping pattern in our cohort (p=0.008, OR: 1.12, 95% confidence interval: 1.03-1.22). Table 1

Age (years) Male sex (n) Left atrial volume index (mL/m2 ) LV mass index (g/m2 ) Mitral E wave (m/s) E/A ratio Lateral e’ (cm/s) E/e’ ratio Vp (cm/s) Pulmonary vein S wave (m/s)

Nondippers (n=77)

Dippers (n=46)

p

59.6±8.9 27 26.7±7.6 99.5±20.3 0.65±0.13 0.79±0.19 7.9±2.6 9.7±2.9 52.9±8.6 0.57±0.11

57.1±8.1 10 21.3±4.5 85.2±15.4 0.72±0.14 0.89±0.22 9.8±3.3 8.7±1.9 56.1±7.3 0.63±0.10

0.21 0.17