Aug 12, 2017 - 1 Pulmonologist, Lung Disease Research Center, School of ... Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran ..... 14) Denton C, Cailes J, Phillips G, Wells A, Black C, Bois Rd.
Electronic Physician (ISSN: 2008-5842)
http://www.ephysician.ir
August 2017, Volume: 9, Issue: 8, Pages: 5122-5128, DOI: http://dx.doi.org/10.19082/5122 Correlation of echocardiographic findings of pulmonary hypertension with six-minute walk test and plasma pro b-type natriuretic peptide level in systemic lupus erythematous Leila Ghofraniha1, Zahra Mirfeizi2, Fatemeh Seyyedi Khabbaz2, Farveh Vakilian3, Saeed Eslami4,5 Pulmonologist, Lung Disease Research Center, School of Medicine, Mashhad University of Medicine Sciences, Mashhad, Iran 2 MD, Associate Professor of Rheumatology, Rheumatic Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 3 Internist, Rheumatic Diseases Research Center, Preventive Atherosclerotic Research Center, Cardiology Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran 4 Internal Medicine, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 5 Department of Medical Informatics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran 1
Type of article: Original Abstract Introduction: Pulmonary arterial hypertension (PAH) is an increasingly recognized complication of systemic lupus erythematous (SLE), which may remain undiagnosed if asymptomatic. Objective: This study aimed to determine the correlation between echocardiographic findings of PAH and sixminute walk test (6WMT) and serum pro b-type natriuretic peptide (proBNP) level in patients with SLE. Methods: This cross-sectional study was performed on 50 SLE patients selected from patients referring to the outpatient’s department of the Rheumatology Clinic at Imam Reza Hospital in Mashhad, Iran, from July 2013 through September 2014, using resting transthoracic echocardiography to estimate systolic pulmonary artery pressure (sPAP). Variables were summarized as counts and/or percentages or as mean±SD. Inter-group comparisons were made performing two-tailed Fisher’s exact test or Mann–Whitney U test, using SPSS 22. Results: In general, five out of fifty patients were diagnosed to have PAH with sPAP>30 mmHg (range: 31-40 mmHg) based on echocardiographic findings. Spirometric parameters did not show any differences between the two groups (p>0.05), while the difference in total distance walked during six minutes and serum proBNP level between SLE patients with and without PAH was significant (P
