Periodontal pathogen CaZymes: host-pathogen biology, biochemistry

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Jun 20, 2017 - Download by: [185.158.102.213]. Date: 20 June 2017, ... biology, biochemistry and biotechnological ... It will also outline basic biochemical and.
Journal of Oral Microbiology

ISSN: (Print) 2000-2297 (Online) Journal homepage: http://www.tandfonline.com/loi/zjom20

Periodontal pathogen CaZymes: host-pathogen biology, biochemistry and biotechnological exploitation Graham P. Stafford, Andrew M. Frey & Marianne J. Satur To cite this article: Graham P. Stafford, Andrew M. Frey & Marianne J. Satur (2017) Periodontal pathogen CaZymes: host-pathogen biology, biochemistry and biotechnological exploitation, Journal of Oral Microbiology, 9:sup1, 1325208, DOI: 10.1080/20002297.2017.1325208 To link to this article: http://dx.doi.org/10.1080/20002297.2017.1325208

© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Published online: 20 Jun 2017.

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Date: 20 June 2017, At: 15:03

JOURNAL OF ORAL MICROBIOLOGY, 2017 SUPPLEMENT, 1325208 https://doi.org/10.1080/20002297.2017.1325208

EOMW Stockholm 2017 – 12th European Oral Microbiology Workshop

Periodontal pathogen CaZymes: host-pathogen biology, biochemistry and biotechnological exploitation Graham P. Stafford, Andrew M. Frey and Marianne J. Satur Integrated BioSciences, School of Clinical Dentistry, University of Sheffield, Sheffield, UK

ABSTRACT

One often neglected aspect of the host-pathogen interface is the presence of myriad glycoproteins and the carbohydrate glycans that they present. These are often the first point of contact for bacteria, with the oral cavity being rich in glycoprotein mucins within secretions such as saliva and crevicular fluid. Therefore, unsurprisingly, bacteria have evolved a myriad of enzymes (that one can consider virulence attributes) to access these glycans to allow attachment to host surfaces, which often results in modulation of host-cell behavior but also that bacteria harvest for nutritional purposes. This talk will summarise our recent work on the role of a range of novel CaZymes from periodontal pathogens in terms of their role in host-bacteria interactions and biofilm formation with potential routes to novel antimicrobials. It will also outline basic biochemical and structural biology work that has identified novel enzymes, lectin domains and biochemical activities that has lead to utilization of these seemingly obscure enzymes in bespoke, specialized biotechnological uses in biopharmaceutical protein analysis that we are currently investigating further.

CONTACT Graham P. Stafford

[email protected]

© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.