Poster Abstracts

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razor, tattoo marking, and homosexuality/hetero sexuality. PURPOSE OF STUDY: ...... A Moradi2 1Iran University of Medical Siences, Tehran, Iran,. 2Golestan ...
Journal of Viral Hepatitis, 2015, 22 (Suppl. S3), 19–49

doi:10.1111/jvh.12441

Poster Abstracts HEPATITIS C VIRUS Diagnosis P1 Can simple easily reproducible biochemical tests replace the costly elastography in diagnosis of liver cirrhosis in chronic hepatitis C patients? H Shabana Mansoura University, Mansoura, Egypt BACKGROUND: In the era of novel antiviral drugs for treat-

ment of chronic viral hepatitis C (HCV), the diagnosis of liver cirrhosis guides both the choice of the drug regimen, duration of treatment and subsequent follow up. Transient elastography (TE) (fibroscan) is a recent, non invasive and reliable method for the diagnosis of cirrhosis in patients with chronic HCV. We aimed at demonstrating the agreement of some of the indirect serum markers of liver fibrosis with TE score in staging of liver fibrosis in chronic HCV patients. MATERIALS AND METHODS: One hundred and fifty-nine chronic HCV Egyptian patients were evaluated for antiviral treatment using TE. In all patients, real-time PCR for HCV RNA, liver and renal biochemical tests, PT, INR and CBC were done just before TE (no longer than one month). The stage of liver fibrosis was considered F0 if TE score was 0– 5, F1 if 5.1–7, F2 if 7.1–10, F3 if 10.1–17 and F4 if it was 17.1–75. Liver fibrosis was considered non significant (NSF) if TE score corresponds to F0 or F1. Liver fibrosis was considered significant (SF) if TE score corresponds to F2 or F3. Liver cirrhosis was diagnosed if it corresponded to F4. The indirect serum markers of liver fibrosis examined were AST/Platelet Ratio Index (APRI), Fibrosis 4 score (FIB4) and fibrosis index (FI). APRI was calculated as (AST/upper limit of normal range)/platelet count (109/ L) 9 100 (1). Liver fibrosis was considered significant if APRI score was ≥0.7 and cirrhosis was considered if the score was ≥1 (2). FIB4 score was calculated using the following formula: (Age 9 AST)/(Platelets 9 (sqr(ALT)). If FIB4 score 3.25 = F3–F4 (3). FI was calculated using the following formula: 8.28  [(0.01 9 Platelets (109/L)  [1.08 * (10 * serum albumin (g/L))]]. If FI