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Potential Factors That May Affect Acceptance of Routine Prenatal HIV Testing Fu-Lin Wang, BMed, PhD1 Bryce Larke, MD, DClSc1 Stephan Gabos, MD1 Anita Hanrahan, RN, MN2 Donald Schopflocher, PhD1

ABSTRACT Background: Despite increasing advocacy for an “opt-out” strategy in routine prenatal HIV screening programs in Canada, no published studies have examined factors that may affect acceptance of prenatal HIV testing. Methods: We included all pregnant women in Alberta who received prenatal care (N=38,712) and their caregivers (N=2,007) between January 1 and November 30, 2000. Factors associated with non-acceptance of HIV testing in both pregnant women and their caregivers were assessed using multivariate logistic regression. Results: Overall, 1.5% of women declined HIV testing. First Nations women were about twice as likely to decline the test (adjusted odds ratio [ORadj] 1.91, 95% CI [1.42-2.58]) compared to non-First Nations women (p