Mar 22, 2013 - Targeting protein dynamics in drug design. Rebecca C Wade1,2. From 8th German Conference on Chemoinformatics: 26 CIC-Workshop.
Jul 13, 2017 - Previously titled: Genome-wide characterization of folate transporter proteins of eukaryotic pathogens. Mofolusho O. .... essential in some eukaryotic pathogens such as Plasmodium, ...... Alam A, Goyal M, Iqbal MS, et al.
Jul 15, 2010 - potential role of p53. Hyun-Cheol Kang ⢠Chae-Yong Kim ⢠Jung Ho Han â¢. Ghee Young Choe ⢠Jae Hyoung Kim ⢠Jee Hyun Kim â¢. In Ah Kim.
is that small molecules readily cross the BBB. A small molecule .... Following ICV injection, the drug readily .... these membranes are separated by an endothelial cytoplasm ...... of brain cancer with an artificial virus gene delivery system. Mol.
A number of techniques such as in-line probing [9], DMS footprinting [10], ... The intervening bases between G-quartets are termed as loops of G-quadruplex .... stringâ model for the quadruplex assembly via stacking of quadruplex blocks upon.
4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.
Sex pheromone communication in the nine. European species of small ermine moths (Yponomeuta) is re- viewed in regard to the potential role of pheromones ...
Feb 2, 2010 - Communicated by: Jean-Marie Saudubray. Competing ..... Tsalikian E, Simmons P, Gerich JE, Howard C, Haymond MW (1984). Glucose ...
nitrogenase activity in the cultured cyanobiont Nostoc ANTH. S. Singh, B.B. Singh and P.S. Bisen*. Ammonium at 5mM completely inhibited nitrogenase activity ...
EDITORIAL. The potential role of forensic pathologists in veterinary forensic medicine. Roger W. Byard ⢠Wayne Boardman. Published online: 17 April 2011.
Nov 28, 2012 - http://www.translational-medicine.com/content/10/S3/O5 ... Inclusion in PubMed, CAS, Scopus and Google Scholar. ⢠Research which is freely ...
maintenance and perhaps evolution of narrow host range in insect herbivores. Keywords: .... Then the top of the cage was opened and the cafeteria cage closed.
Aug 30, 2013 - The role of chronic bronchitis remains contro- versial though. A relatively recently realized feature of COPD is in- tense bronchial inflammation ...
Aug 11, 2012 - β-glycosidic linkages to one of several positions onto a neighbouring ...... LCPDCPLLAPLNDSR of bovine alpha-2-HS-glycoprotein. b CID-.
Tamoxifen (L02BA01), and Voriconazole (J02AC03) a exclusive cotrimoxazole and metronidazole; b Exclusive azapropazone and phenylbutazone; c Applies to ...
Role of AVP-AQP2 System on Endolymphatic Hydrops and its Treatment . ... in the formation of endolymphatic hydrops which is the most common histological.
caffeine). Healthy subjects, with a history of normal renal function, were used as controls. In this study ... treatment could cause MOH (i.e. ergotamine derivatives,.
Sep 8, 2012 - acid sulfate soils or sodic soils, respectively (Brady and Weil 2010). ..... Potassium, sodium, and aluminum solubility is not directly affected by ...
Oct 4, 2012 - as sulfamethazine-theophylline, pyrazinamide-diflunisal, sulfamethazine-potassium salt of 4-aminobenzoic acid, theophylline: gentisic acid ...
Moreover, cell-penetrating peptides (CPP) can cross the cell plasma membrane and deliver conjugated protein, nucleic acid, or any other cargo to the cytoplasm ...
development. While a few of ... sequential cleavage of b-amyloid precursor protein (APP) by .... be exciting news for AD patients in their late stages, if nascent ...
and clinicopathological significance of CDH1 promoter methylation and lung cancer remains unclear. In this study, we systematically reviewed the studies of ...
Feb 17, 2009 - species in cancer prevention and therapy ... Abstract Phytochemical research has revealed that ... Agency for Healthcare Research and. Quality.
Aug 28, 2012 - reactivity effect [10,12,14], supporting the view that an ac- tive therapeutic process is .... on the 10-item Drug Abuse Screening Test (DAST-10).
uronide prodrugs of anticancer agents. Key words β-Glucuronidase · Human pancreas ·. Pancreatic cancer · Glucuronide prodrug · Drug targeting. Introduction.
Bernhard Sperker · Ulrike Werner · Thomas E. Mürdter · Ceren Tekkaya · Peter Fritz · Rainer Wacke · Ulrich Adam · Manfred Gerken · Bernd Drewelow · Heyo K. Kroemer
Abstract Improvement of non-surgical strategies is a pivotal task in the treatment of pancreatic cancer. Response to treatment with most anticancer agents has been very poor, probably due to insufficient drug concentration in tumor tissue. Increased response rates during chemotherapy might be achieved by dose escalation; however, this approach is often hampered by severe side effects. One strategy to overcome these adverse effects is application of nontoxic glucuronide prodrugs from which the active moiety is released by β-glucuronidase within or near the tumor. The use of glucuronide prodrugs in pancreatic cancer requires increased expression of the enzyme in the diseased tissue, a problem that has not been addressed so far. We therefore investigated function and expression of β-glucuronidase in tissue samples from human healthy pancreas (n=7) and pancreatic adenocarcinoma (n=8), respectively. Comparing the ability of tissue homogenates to cleave the standard substrate 4-methylumbelliferyl-βD-glucuronide, we found a significantly increased specific β-glucuronidase activity (P
