Protegrins: Structural Requirements for ... - Infection and Immunity

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We tested 20 protegrins against Chlamydia trachomatis serovar L2 (L2/434/Bu). Five of the protegrins had native structures; the others included nonamidated, ...
INFECTION AND IMMUNITY, Nov. 1996, p. 4863–4866 0019-9567/96/$04.0010 Copyright q 1996, American Society for Microbiology

Vol. 64, No. 11

Protegrins: Structural Requirements for Inactivating Elementary Bodies of Chlamydia trachomatis BUSHRA YASIN,1 ROBERT I. LEHRER,2 SYLVIA S. L. HARWIG,2

AND

ELIZABETH A. WAGAR1*

1

Department of Pathology and Laboratory Medicine, and Section of Molecular Host Defense, Department of Medicine,2 UCLA School of Medicine, Los Angeles, California 90095 Received 10 April 1996/Returned for modification 24 July 1996/Accepted 20 August 1996

We tested 20 protegrins against Chlamydia trachomatis serovar L2 (L2/434/Bu). Five of the protegrins had native structures; the others included nonamidated, enantiomeric, and truncated variants and peptides with