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tice and research to date has a single-disease-based paradigm, which may not ... Studies, Flinders University,. Adelaide ... Australia; gillian.caughey@unisa.edu.au ... University of South Australia additionally approved the design upon which ...
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Caughey, Gillian Elizabeth; Ramsay, Emmae Nicole; Vitry, Agnes; Gilbert, A. L.; Luszcz, Mary; Ryan, Philip; Roughead, Elizabeth E.. Comorbid chronic diseases, discordant impact on mortality in older people: a 14-year longitudinal population study, Journal of Epidemiology and Community Health, 2010; 64(12):1036-1042.

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http://hdl.handle.net/2440/62696 26th September 2011

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Research report

Comorbid chronic diseases, discordant impact on mortality in older people: a 14-year longitudinal population study G E Caughey,1 E N Ramsay,2 A I Vitry,1 A L Gilbert,1 M A Luszcz,3 P Ryan,2 E E Roughead1 1

Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia 2 Discipline of Public Health, University of Adelaide, Adelaide, Australia 3 School of Psychology and Flinders Centre for Ageing Studies, Flinders University, Adelaide, Australia Correspondence to Dr Gillian E Caughey, Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, GPO Box 2471, Adelaide 5001, Australia; [email protected] Accepted 1 October 2009 Published Online First 23 October 2009

ABSTRACT Objectives To determine the impact of comorbid chronic diseases on mortality in older people. Design Prospective cohort study (1992e2006). Associations between numbers of chronic diseases or mutually exclusive comorbid chronic diseases on mortality over 14 years, by Cox proportional hazards model adjusting for sociodemographic variables or KaplaneMeier analyses, respectively. Setting Population based, Australia. Participants 2087 randomly selected participants aged $65 years old, living in the community or institutions. Main results Participants with 3e4 or $5 diseases had a 25% (95% CI 1.05 to 1.5, p¼0.01) and 80% (95% CI 1.5 to 2.2, p