Q U I N T E S S E N C E I N T E R N AT I O N A L
Randomized trial of aloe vera gel vs triamcinolone acetonide ointment in the treatment of oral lichen planus 3FEEZ-BWBOZB3FEEZ .%413FEEZ4VEIBLBSB3FEEZ .%42/ 5BUBQVEJ3BNFTI .%435IBLVSJ3BKFTI4JOHI .%44/ -JOHBN"NBSB4XBQOB .%41/JNNB7JKBZB-BYNJ .%41
Objective:5PEFUFSNJOFUIFFGGFDUJWFOFTTPGBMPFWFSBHFMJOUIFUSFBUNFOUPGPSBM MJDIFOQMBOVTXIFODPNQBSFEXJUIUSJBNDJOPMPOFBDFUPOJEFMethod and Materials:" SBOEPNJ[FE EPVCMFCMJOE DMJOJDBMUSJBMXBTEFTJHOFE5IFTUVEZTBNQMFDPOTUJUVUFE QBUJFOUT NBMFTBOEGFNBMFT XIPXFSFSBOEPNMZEJWJEFEJOUPUXPFRVBMHSPVQT (SPVQ"QBUJFOUTSFDFJWFEBMPFWFSBHFM XIJMFHSPVQ#QBUJFOUTSFDFJWFEUSJBNDJOPMPOF BDFUPOJEFResults:'PSUZQBUJFOUTXFSFJODMVEFEJOUIFTUVEZ.PTUPGUIFTBNQMF QSFTFOUFEXJUIFSPTJWF O BOEBUSPQIJD O WBSJBOUTPGPSBMMJDIFOQMBOVT 8IFODMJOJDBMTJHOTBOETZNQUPNTXFSFPCTFSWFEBGUFSXFFLTPGUIFSBQZ JUXBT EFUFSNJOFEUIBUBMPFWFSBHFMXBTNPSFFGGFDUJWFUIBOUSJBNDJOPMPOFBDFUPOJEFJOUIF USFBUNFOUPGPSBMMJDIFOQMBOVTConclusion:"MPFWFSBHFMDBOCFDPOTJEFSFEBTBGF BMUFSOBUJWFUSFBUNFOUGPSPSBMMJDIFOQMBOVT(Quintessence Int 2012;43:793–800)
Key words:BMPFWFSBHFM CVSOJOHTFOTBUJPO IFBMJOH PSBMMJDIFOQMBOVT USJBNDJOPMPOFBDFUPOJEF
-JDIFOQMBOVTJTBSFMBUJWFMZDPNNPODISPO-
3FUJDVMBS QBQVMBS BOE QMBRVF MFTJPOT TFM-
JD JOGMBNNBUPSZ NVDPDVUBOFPVT EJTPSEFS
EPN QSFTFOU XJUI BOZ TZNQUPNT 5IFZ BSF
UIBUBGGFDUTUIFTLJOBOEPSBMNVDPTB1 0SBM
VTVBMMZBTZNQUPNBUJDBOEGPVOEVQPOSPV-
MJDIFOQMBOVTJTFTUJNBUFEUPBGGFDUUP
UJOF PSBM FYBNJOBUJPO )PXFWFS BUSPQIJD
PG JOEJWJEVBMT2 5IF QSFWBMFODF SBUF
FSPTJWF BOE CVMMPVT MFTJPOT DBVTF DPN-
NBZ EJGGFS BNPOH SBDFT BOE HFPHSBQIJD
QMBJOUTPGQBJOPSCVSOJOHTFOTBUJPOT8
3
BSFBT "MUIPVHI UIF FYBDU DBVTF PG PSBM
$VSSFOU USFBUNFOU NPEBMJUJFT GPS PSBM
MJDIFO QMBOVT JT BNCJHVPVT FYQFSJNFOUBM
MJDIFO QMBOVT BSF BJNFE BU BMMFWJBUJOH UIF
FWJEFODFTVHHFTUTUIBUJUJTBOJOGMBNNBUPSZ
QBJOPSCVSOJOHTFOTBUJPOBOEFMJNJOBUJOHUIF
5DFMMoNFEJBUFEJNNVOFSFTQPOTF4
MFTJPOT"XJEFSBOHFPGUIFSBQFVUJDBHFOUT
0SBM MJDIFO QMBOVT MFTJPOT BSF DMJOJDBMMZ
JODMVEJOH DPSUJDPTUFSPJET SFUJOPJET BOUJNZ-
DMBTTJGJFE BT SFUJDVMBS BUSPQIJD QBQVMBS
DPUJDT B[BUIJPQSJOF DZDMPTQPSJOF UBDSPMJ-
QMBRVFFODSVTUFE FSPTJWF BOE CVMMPVT5–7
NVT QIPUPDIFNPUIFSQZ BOE TVSHFSZ IBWF CFFO VTFE GPS UIF USFBUNFOU PG PSBM MJDIFO QMBOVT
1
1BUJFOUTXJUITZNQUPNBUJDPSBMMJDIFOQMB-
Postgraduate Student, Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
OVTPGUFOSFRVJSFJOUFOTJWFUIFSBQZUPBMMJFWJBUF JUTTJHOTBOETZNQUPNT/PUSFBUNFOUNPEBM-
2
Professor and Head, Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, Andhra
3
4
JUZQSPWJEFTDPNQMFUFSFTPMVUJPOPGUIFMFTJPO
Pradesh, India.
UIFSFGPSF UIFNBOBHFNFOUTUSBUFHZGPDVTFT
Associate Professor, Department of Oral Medicine and
POUIFVTFPGESVHTUIBUDPVOUFSUJTTVFJOGMBN-
Radiology, Vishnu Dental College, Bhimavaram, Andhra
NBUJPO BOE UIFJS VOEFSMZJOH JNNVOPMPHJD
Pradesh, India.
NFDIBOJTNT10.BOZQMBOUTBSFVTFEJONFE-
Assistant Professor, Department of Oral Medicine and
JDJOF GPS USFBUJOH WBSJPVT EJTFBTFT BOE BMPF
Radiology, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India. Correspondence: Dr Reddy Lavanya Reddy, Vishnu Dental College, Gangipelli, Madal: Manakodur, Karimnagar, Andhra Pradesh, 505474, India. Email:
[email protected]
WFSBJTPOFBNPOHUIFN*UJTBDPNQMFYQMBOU DPOUBJOJOH CJPMPHJDBMMZ BDUJWF TVCTUBODFT XJUIQSPQFSUJFTUIBUFOIBODFUIFJNNVOFTZTUFNUPDPNCBUNBOZPSBMEJTFBTFT11–13
VOLUME 43 t /6.#&39 t 0$50#&3 2012
793
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
"MPF WFSB JT B DBDUVTMJLF QMBOU UIBU
DPOUBJOFST XBT EPOF CZ UIF JOWFTUJHBUPS
CFMPOHT UP UIF MJMJBDFBF GBNJMZ *U DPOUBJOT
BOEEJTDMPTFEBUUIFFOEPGUIFDMJOJDBMUSJBM
QPUFOUJBMMZ BDUJWF DPOTUJUVFOUT JODMVE-
XFFLT 5XP PQFSBUPST XFSF BTTJHOFE
JOH WJUBNJOT FO[ZNFT NJOFSBMT TVHBST
UP DMJOJDBMMZ TDSFFO UIF MFTJPOT 5IFZ XFSF
MJHOJOT TBQPOJOT TBMJDZMJDBDJET BOEBNJOP
USBJOFEUPHSBEFUIFMFTJPO11 GPSUIFCVSOJOH
BDJET14*UIBTBMPOHIJTUPSZPGQPQVMBSVTF
TFOTBUJPO BWJTVBMBOBMPHTDBMF 7"4 XBT
BOEJUTUPQJDBMBQQMJDBUJPOJTHFOFSBMMZDPO-
GPMMPXFE
TJEFSFEUPCFTBGF15
(SPVQ"QBUJFOUTSFDFJWFECMVFNFEJDB-
4FWFSBMUPQJDBMBOETZTUFNJDUSFBUNFOUT
NFOU DPOUBJOFST BOE BMM HSPVQ # QBUJFOUT
BSFBWBJMBCMFGPSPSBMMJDIFOQMBOVTQBUJFOUT
SFDFJWFE QJOL NFEJDBNFOU DPOUBJOFST 5IF
CVUUIFSBQFVUJDSFTQPOTFTNBZEJGGFS
QBUJFOUTXFSFJOTUSVDUFEUPBQQMZUIFNFEJ-
1SFWJPVT TUVEJFT IBWF QSPWFO UIBU JO
DBUJPO UISFF UJNFT EBJMZ *G BOZ BMMFSHJD
DPNQBSJTPO XJUI B QMBDFCP BMPF WFSB JT
NBOJGFTUBUJPOTXFSFTFFOBGUFSGJSTUBQQMZJOH
FGGFDUJWF JO UIF USFBUNFOU PG PSBM MJDIFO
UIF QSFTDSJCFE NFEJDBNFOU QBUJFOUT XFSF
QMBOVT 5IFSF IBT CFFO OP TUVEZ DPN-
BTLFE UP TUPQ NFEJDBUJPO BOE JNNFEJBUFMZ
QBSJOHBMPFWFSBHFMBOEUSJBNDJOPMPOFBDF-
SFQPSUUPUIFIPTQJUBM
UPOJEFJOUIFUSFBUNFOUPGPSBMMJDIFOQMBOVT
1BUJFOUT XFSF SFDBMMFE GPS QFSJPEJD
5IFSFGPSF UIFQSFTFOUTUVEZXBTEFTJHOFE
SFWJFX BU UIF OE UI UI BOE UI XFFLT
UPFWBMVBUFUIFFGGJDBDZPGUPQJDBMBMPFWFSB
$MJOJDBMMZ UIF MPDBUJPO PG UIF MFTJPOT XBT
HFM JO UIF USFBUNFOU PG PSBM MJDIFO QMBOVT
SFDPSEFE11 OPMFTJPO NJMEXIJUFTUSJBF
DPNQBSFEXJUIUSJBNDJOPMPOFBDFUPOJEF
XIJUF TUSJBF XJUI BUSPQIJD BSFB MFTT UIBO DN XIJUFTUSJBFXJUIBUSPQIJDBSFBNPSF UIBO DN XIJUF TUSJBF XJUI BO FSPTJWF BSFB MFTT UIBO DN BOE XIJUF TUSJBF
METHOD AND MATERIALS
XJUI BO FSPTJWF BSFB NPSF UIBO DN PS BO VMDFSBUJWF MFTJPO "OZ CVSOJOH TFOTBUJPO XBTTDPSFECZ7"41BUJFOUTXFSFBTLFEUP
5IF QSFTFOU TUVEZ XBT EFTJHOFE XJUI UIF
TDPSFUIFJSJOUFOTJUZPGCVSOJOHTFOTBUJPOBU
NBJOPCKFDUJWFPGEFUFSNJOJOHUIFFGGFDUJWF-
FBDI WJTJU 4DPSFT SBOHFE GSPN OP QBJO
OFTTPGBMPFWFSBHFMJOUIFUSFBUNFOUPGPSBM
UP FYUSFNFQBJO
MJDIFO QMBOVT XIFO DPNQBSFE XJUI USJBNDJOPMPOF BDFUPOJEF 5IF BMPF WFSB HFM XBT
5SFBUNFOUSFTQPOTFXBTHSBEFEBTDPNQMFUF XIFO UIF TDPSFT11 XFSF FJUIFS PS
QSFQBSFEBDDPSEJOHUPQSFWJPVTTUVEJFT
HPPE XIFO TDPSFT EFDSFBTFE CZ ö
5IF TUVEZ QSPUPDPM XBT BQQSPWFE CZ UIF
GSPNCBTFMJOF QPPSXIFOTDPSFTEFDSFBTFE
*OTUJUVUJPOBM&UIJDBM3FWJFX#PBSEPG7JTIOV
CZ GSPNCBTFMJOF BOEBTOPSFTQPOTF
%FOUBM
XIFOUIFMFTJPOTXFSFVODIBOHFE$PNQMFUF
$PMMFHF
#IJNBWBSBN
"OEISB
1SBEFTI *OEJB *&3# 7%$0.3
SFTPMVUJPO PG UIF TZNQUPNT XBT EFGJOFE BT BO BCTFODF PG CVSOJOH TFOTBUJPO 7"4
Methodology
TDPSF (PPE QPPS PSOPSFTQPOTFPGUIF
5IF TUVEZ TBNQMF DPNQSJTFE QBUJFOUT
TZNQUPNBUPMPHZXBTEFGJOFEBTBEFDSFBTF
XIPXFSFSBOEPNMZEJWJEFEJOUPUXPHSPVQT
PG ö B EFDSFBTF PG PS OP
PG QBUJFOUT FBDI (SPVQ " TVCKFDUT
DIBOHF SFTQFDUJWFMZ JO7"4TDPSFT
SFDFJWFE BMPF WFSB HFM UFTU HSPVQ
BOE HSPVQ # TVCKFDUT SFDFJWFE USJBNDJOPMPOF BDFUPOJEF DPOUSPMHSPVQ #PUI UIF PQFSBUPS BOE QBUJFOU XFSF
RESULTS
VOBXBSFPGNFEJDBNFOUVTFE5IFCMJOEJOH XBTQFSGPSNFECZDPMPSDPEJOHUIFDPOUBJOFST GSPN XIJDI UIF NFEJDBNFOU XBT EJT-
5IF EBUB XFSF BOBMZ[FE VTJOH 4144
QFOTFE*EFOUJDBMPQBRVFTUFSJMFDPOUBJOFST
*#. 5IF .BOO8IJUOFZ U UFTU XBT
XJUI NFEJDBNFOU XFSF DPMPSDPEFE CZ BO
VTFE GPS JOUFSHSPVQ DPNQBSJTPO BOE UIF
JOWFTUJHBUPS%JTQFOTJOHPGUIFNFEJDBNFOU
8JMDPYPO NBUDIFE QBJST UFTU CZ SBOLT XBT
BMPF WFSB PS USJBNDJOPMPOF BDFUPOJEF JOUP
VTFE GPS JOUSBHSPVQ DPNQBSJTPO 4UBUJTUJDBM
UIF QBSUJDVMBS DPMPSDPEFE CMVF PS QJOL
TJHOJGJDBODFXBTTFUBUP
794
VOLUME 43 t /6.#&39 t 0$50#&3 2012
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
Table 1
Comparison of control and study groups with respect to clinical score at different time intervals U value
Z value
P value
o
o
4 wk $POUSPM 4UVEZ
o
6 wk $POUSPM 4UVEZ
o
8 wk $POUSPM 4UVEZ
o
Group
Mean ± SD
Initial visit $POUSPM 4UVEZ
2 wk $POUSPM 4UVEZ
Sum of ranks
P .BOO8IJUOFZ6UFTU 4% TUBOEBSEEFWJBUJPO
5IF UPUBM TBNQMF JODMVEFE QBUJFOUT BNPOH XIPN XFSF NBMFT BOE
HSPVQT BO JOTJHOJGJDBOU EJGGFSFODF XBT PCTFSWFE XJUI SFTQFDU UP DMJOJDBM TDPSFT ; o P BU UIF MFWFM PG
Mean value
XFSF GFNBMFT 0O DPNQBSJTPO PG DMJOJDBM TDPSFT JO UIF DPOUSPM BOE TUVEZ
TJHOJGJDBODF 5IJT NFBOT UIBU UIF DMJOJDBM TDPSFT BU UIF JOJUJBM WJTJU XFSF TJNJMBS JO UIF DPOUSPMBOETUVEZHSPVQT " TJHOJGJDBOU EJGGFSFODF XBT PCTFSWFE
9.00 8.00 7.00 6.00 5.00 4.00 3.00 2.00 1.00 0.00
7.00 5.20 3.80
Initial visit
CFUXFFO DPOUSPM BOE TUVEZ HSPVQT XJUI SFTQFDU UP DMJOJDBM TDPSFT BU UIF OE ; o P
UI ; o P
UI ; o P
BOE UI XFFLT
2 wk
2.45
2.15
4 wk 6 wk Control group
8 wk
Fig 1 Comparison of the burning sensation in the control group at different time intervals.
; o P BU B MFWFM PG TJHOJGJDBODF 5IJT NFBOT UIBU UIF DMJOJDBM
" TJHOJGJDBOU EJGGFSFODF XBT PCTFSWFE
TDPSFT BU UIF OE UI UI BOE UI XFFL
BNPOHEJGGFSFOUUJNFQFSJPETFYDFQUCFUXFFO
XFSF EJGGFSFOU JO UIF DPOUSPM BOE TUVEZ
BOEXFFLTXJUISFTQFDUUPDMJOJDBMTDPSFT
HSPVQT$MJOJDBMTDPSFTBNPOHTUVEZHSPVQ
JO UIF DPOUSPM HSPVQ 5IJT TIPXT UIBU BT UIF
XFSF MFTT XIFO DPNQBSFE UP UIF DPOUSPM
UJNF JOUFSWBM JODSFBTFT UIF DMJOJDBM TDPSFT
HSPVQ BU UIF FOE PG OE UI UI BOE UI
PG UIF MFTJPO EFDSFBTFE XJUI SFTQFDU UP UIF
XFFLT 5BCMF 5IFSF XBT OP TUBUJTUJDBM TJHOJGJDBODF
JOJUJBM WJTJU 8IFO UIF DMJOJDBM TDPSFT PG UIF MFTJPO XFSF DPNQBSFE CFUXFFO UIF DPOUSPM
P PCTFSWFE CFUXFFO UIF TUVEZ BOE
HSPVQT BU EJGGFSFOU UJNF JOUFSWBMT TUBUJTUJDBM
DPOUSPM HSPVQ BU UIF JOJUJBM MFTJPO BOE UIF
TJHOJGJDBODF XBT GPVOE FYDFQU GPS UIF UI
OE UI UI BOE UI XFFLT 5IJT NFBOT
BOEUIXFFLJOUFSWBMT5IJTTIPXTUIBUUIFSF
UIBU CVSOJOH TFOTBUJPO TDPSFT XFSF TJNJMBS
XBTOPUNVDIEJGGFSFODFJOUIFDMJOJDBMTDPSF
JOCPUIHSPVQTBUUIFJOJUJBMWJTJUBOEUIFOE
CFUXFFOUIFUIBOEUIXFFLJOUFSWBMTJOUIF
UI UI BOEUIXFFLT
DPOUSPMHSPVQ 'JH
VOLUME 43 t /6.#&39 t 0$50#&3 2012
795
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
Table 2
Comparison of burning sensation scores in the control group Mean
SD
Mean difference
SD difference
% change
Z value
P value
*OJUJBMWJTJU XL
*OJUJBMWJTJU XL
*OJUJBMWJTJU XL
*OJUJBMWJTJU XL
XL XL
XL XL
XL XL
XL XL
XL XL
XL XL
P 8JMDPYPONBUDIFEQBJSTUFTUCZSBOLT 4% TUBOEBSEEFWJBUJPO
" TJHOJGJDBOU EJGGFSFODF XBT PCTFSWFE
JO UIF TUVEZ HSPVQ QSFTFOUFE XJUI TDPSFT
BNPOH EJGGFSFOU UJNF QFSJPET FYDFQU
BOE TIPXJOH DPNQMFUF SFTQPOTF
CFUXFFOUIFUIBOEUIXFFLXJUISFTQFDU
TVCKFDUTQSFTFOUFEXJUITDPSF TIPXJOH
UP CVSOJOH TFOTBUJPO TDPSFT JO UIF DPOUSPM
HPPESFTQPOTF
BOETVCKFDUTXJUITDPSF
HSPVQ 5BCMF
TIPXJOH QPPS SFTQPOTF UP UIF UIFSBQZ
5IF DMJOJDBM TDPSFT PG UIF MFTJPOT XFSF DPNQBSFEJOUIFTUVEZHSPVQXJUISFTQFDUUP
*O UIF DPOUSPM HSPVQ PG QBUJFOUT QSFTFOUFE XJUI TDPSFT BOE DPNQMFUF
UIFJOJUJBMWJTJUBOEBUOE UI UI BOEUI
SFTQPOTF
XIFSFTVCKFDUTQSFTFOUFEXJUI
XFFLT " TUBUJTUJDBMMZ TJHOJGJDBOU EJGGFSFODF
TDPSF HPPESFTQPOTF
XIFSFBTTVCKFDU
XBTPCTFSWFE P 5IJTTIPXTUIBUBT
XJUITDPSF QPPSSFTQPOTF BOETVCKFDUT
UJNF JOUFSWBM JODSFBTFT UIF DMJOJDBM TDPSFT
QSFTFOUFE XJUI TDPSF OP DIBOHF PG UIF
PG UIF MFTJPO JO TUVEZ HSPVQ EFDSFBTFE
MFTJPO BUUIFFOEPGUIFUIFSBQZ 5BCMF 5IF CVSOJOH TDPSF JO UIF UPUBM TBNQMF
5BCMF 5IF CVSOJOH TFOTBUJPO PG UIF MFTJPOT
BU UIF FOE PG UIF UIFSBQZ XFFLT XBT
XFSFDPNQBSFEJOTUVEZHSPVQXJUISFTQFDU
PCTFSWFE JO CPUI HSPVQT *O UIF TUVEZ
UPCVSOJOHTFOTBUJPOTDPSFPGJOJUJBMMFTJPOBU
HSPVQ QBUJFOUT QSFTFOUFE XJUI TDPSF
UIF OE UI UI BOE UI XFFLT " TUBUJTUJ-
DPNQMFUF SFNJTTJPO PG TZNQUPNBUPMPHZ
DBMMZ TJHOJGJDBOU EJGGFSFODF XBT PCTFSWFE
BOE QBUJFOUT TIPXFE TDPSFT ö GSPN
P 5IJT TIPXT UIBU BT UJNF JOUFSWBM
CBTFMJOF *O UIF DPOUSPM HSPVQ UIFSF XFSF
JODSFBTFT UIF CVSOJOH TFOTBUJPO TDPSF PG
QBUJFOUT XJUI TDPSF DPNQMFUF SFNJT-
UIFMFTJPOTJOTUVEZHSPVQEFDSFBTFE 'JH
TJPO
QBUJFOUT XJUI TDPSF ö GSPN
5IF DMJOJDBM TJHOT JO UIF UPUBM TBNQMF
CBTFMJOF BOE QBUJFOUT XJUI TDPSF
BU UIF FOE PG UIF UIFSBQZ XFFLT XBT
GSPN CBTFMJOF PCTFSWFE BU FOE PG UIF UIFS-
PCTFSWFE JO CPUI HSPVQT 'JGUFFO QBUJFOUT
BQZ 5BCMF
796
VOLUME 43 t /6.#&39 t 0$50#&3 2012
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
Table 3
Comparison of clinical scores in the study group Mean
SD
Mean difference
SD difference
% change
Z value
P value
*OJUJBMWJTJU XL
*OJUJBMWJTJU XL
*OJUJBMWJTJU XL
*OJUJBMWJTJU XL
XL XL
XL XL
XL XL
XL XL
XL XL
XL XL
P 8JMDPYPONBUDIFEQBJSTUFTUCZSBOLT 4% TUBOEBSEEFWJBUJPO
Mean value
Fig 2 Comparision of burning sensation in the study group at different time intervals.
Table 4 Scores 0
9.00 8.00 7.00 6.00 5.00 4.00 3.00 2.00 1.00 0.00
6.60 3.90 2.45
Initial visit
2 wk
4 wk Study group
1.10
1.00
6 wk
8 wk
Clinical scores at 8 weeks in the study population Triamcinolone acetonide group
%
Aloe vera gel group
%
Total
3
15
9
45
12
1
6
30
6
30
12
2
8
40
3
15
11
3
1
5
2
10
3
4
2
10
0
0
2
VOLUME 43 t /6.#&39 t 0$50#&3 2012
797
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
Table 5 Scores
Burning sensation at 8 weeks in the study population Triamcinolone acetonide group
%
Aloe vera gel group
%
Total
75
25
0
0
3
2
10
3
0
1
5
1
4
20
2
10
6
1
5
0
0
1
1
5
0
0
1
0
10
50
15
2
3
15
3
1
5
4
0
5 6 8
DISCUSSION
OJGJDBOU P BTTPDJBUJPOXBTPCTFSWFE CFUXFFOUIFTUVEZBOEDPOUSPMHSPVQT5IJT NFBOT UIBU CVSOJOH TFOTBUJPO TDPSFT XFSF
-JDIFO QMBOVT JT B DISPOJD JOGMBNNBUPSZ
TJNJMBSJOCPUIHSPVQTBUBMMUJNFT#PUIUIF
EJTFBTFUIBUDPNNPOMZBGGFDUTTLJOBOEPSBM
NFEJDBNFOUTIBWFQPUFOUBOUJJOGMBNNBUPSZ
NVDPTB*UIBTBOVNCFSPGXFMMSFDPHOJ[FE
BDUJPOT
DMJOJDBM TJHOT BOE B XJEF SBOHF PG TZNQUPNT GSPN OPOF BTZNQUPNBUJD UP NJME
5IFCVSOJOHTFOTBUJPOPGUIFMFTJPOTXFSF DPNQBSFE JO CPUI HSPVQT XJUI SFTQFDU UP
EJTDPNGPSU UP TFWFSF EFCJMJUBUJOH JOUSBPSBM
CVSOJOH TFOTBUJPO TDPSF BU UIF JOJUJBM MFTJPO
MFTJPOT
BOEUIFOE UI UI BOEUIXFFLT"TUB-
'PSUZQBUJFOUT NBMFTBOEGFNBMFT
UJTUJDBMMZTJHOJGJDBOUEJGGFSFODFXBTPCTFSWFE
XFSF JODMVEFE JO UIF TUVEZ .PTU PG UIF
P JO CPUI HSPVQT VOUJM UIF UI XFFL
TBNQMF QSFTFOUFE XJUI FSPTJWF O
CVU UIF TUBUJTUJDBMMZ TJHOJGJDBOU EJGGFSFODF
BOEBUSPQIJD O WBSJBOUTPGPSBMMJDIFO
DPOUJOVFE JO UIF TUVEZ HSPVQ VOUJM UIF FOE
QMBOVT5IFNPTUDPNNPOTJUFPGPSBMMJDIFO
PG UIFSBQZ 5IJT TIPXT UIBU BT UIF UJNF
QMBOVT XBT UIF CVDDBM NVDPTB GPMMPXFE CZ
JOUFSWBM JODSFBTFE UIF CVSOJOH TFOTBUJPO
UIFHJOHJWB
TDPSF PG UIF MFTJPOT EFDSFBTFE DPOUJOV-
*O UIF QSFTFOU TUVEZ BMPF WFSB HFM XBT
PVTMZ JO QBUJFOUT XIP SFDFJWFE BMPF WFSB
NPSFFGGFDUJWFJOJNQSPWJOHDMJOJDBMTDPSF JO
HFM USFBUNFOU 5IJT NFBOT UIBU B SFEVDUJPO
TIPSUFOJOH UIF EVSBUJPO PG XPVOE IFBMJOH
PG CVSOJOH TFOTBUJPO XBT PCTFSWFE XJUI BO
'JHTBOE DPNQBSFEXJUIUSJBNDJOPMPOF
JODSFBTF JO UIF UJNF JOUFSWBM 5IJT NJHIU CF
BDFUPOJEF5IJTGJOEJOHXBTTJNJMBSUPUIBUPG
EVF UP UIF BCJMJUZ PG BMPF WFSB UP QFOFUSBUF
)BZFT 17 XIPSFQPSUFEBDBTFPGTVDDFTTGVM
UIF UJTTVF SFTVMUJOH JO CSJOHJOH UIF NFEJDB-
USFBUNFOU PG MJDIFO QMBOVT XJUI BMPF WFSB
NFOU UP UIF BSFB OFFEJOH JU17 5IJT IFMQT JO
$IPPOIBLBSOFUBM11SFQPSUFEUIBUBMPFWFSB
SFMJFWJOHCVSOJOHTFOTBUJPOCZJOBDUJWBUJOHPS
XBTFGGFDUJWFJOUIFUSFBUNFOUPGPSBMMJDIFO
JOUFSGFSJOH XJUI UIF BSBDIJEPOJD QBUIXBZ WJB
QMBOVT DPNQBSFE XJUI B QMBDFCP BOE
DZDMPPYZHFOBTF
18
4BMB[BS4ÈODIF[FUBM DPODMVEFEUIBUUPQJDBMBQQMJDBUJPOPGBMPFWFSBJNQSPWFTRVBMJUZ
8IFO DMJOJDBM TJHOT BOE CVSOJOH TFOTBUJPOTDPSFTXFSFPCTFSWFEBUUIFFOEPGUIF
PGMJGFTDPSFTJOQBUJFOUTXJUIPSBMMJDIFOQMB-
UIFSBQZ UIXFFL TFF'JHTBOE
CFU-
OVT 5IJT JT CFDBVTF BMPF WFSB DBO JOIJCJU
UFS DMJOJDBM BOE TZNQUPNBUPMPHJD JNQSPWF-
UIF JOGMBNNBUPSZ QSPDFTT CZ JUT JOUFSGFSJOH
NFOUXBTPCTFSWFEJOUIFTBNQMFSFDFJWJOH
BDUJPO PO UIF BSDIJEPOJD BDJE QBUIXBZ WJB
BMPFWFSBHFMUIBOUSJBNDJOPMPOFBDFUPOJEF
DZDMPPYZHFOBTF 3FDFOU EBUB TVHHFTU UIBU
5IJT NJHIU CF EVF UP GBTUFS IFBMJOH PG UIF
BMPFWFSBBMTPIBTBOUJJOGMBNNBUPSZFGGFDUT
MFTJPO UIBU NBZ CF BUUSJCVUFE UP UIF QSFT-
CZUIFSFEVDUJPOPGMFVLPDZUFBEIFTJPOBOE
FODF PG BDUJWF HSPXUI GBDUPS NBOOPTF
5/'αMFWFM
QIPTQIBUF MJLF UIF TVCTUBODF JO BMPF
8IFOCVSOJOHTFOTBUJPOTDPSFTBUEJGGFSFOUUJNFJOUFSWBMT XFSFDPNQBSFE BOJOTJH-
798
WFSB XIJDI FOIBODFT GJCSPCMBTUJD BDUJWJUZ SFTVMUJOHJOUJTTVFSFQBJS
VOLUME 43 t /6.#&39 t 0$50#&3 2012
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
Fig 3 Photographs of study group patient.
Fig 4
Photographs of the aloe vera patient.
VOLUME 43 t /6.#&39 t 0$50#&3 2012
799
Q U I N T E S S E N C E I N T E R N AT I O N A L Reddy et al
CONCLUSION
6. McCarthy PL, Shklar G. Diseases of the Oral Mucosa, ed 2. Philadelphia: Febiger Philadelphia, 1980:203–224. 7. Huber MA. Oral lichen planus. Quintessence Int 2004;
"MPFWFSBHFMXBTFGGFDUJWFJOSFEVDJOHCPUI
35:731–752.
DMJOJDBMTJHOTBOECVSOJOHTFOTBUJPOTPGUIF
8. Dusek JJ, Frick WG. Lichen planus: Oral manifesta-
MFTJPO XIFO DPNQBSFE XJUI USJBNDJOPMPOF
tions and suggested treatments. J Oral Maxillofac
BDFUPOJEF 5IVT BMPF WFSB HFM JT TBGF BOE FGGFDUJWFJOUIFUSFBUNFOUPGPSBMMJDIFOQMBOVT 4JODF UIFSF XFSF GFX DMJOJDBM SFQPSUT JO UIF MJUFSBUVSF SFHBSEJOH JUT FGGFDUJWFOFTT GVSUIFSSFTFBSDIJTSFRVJSFE
Surg 1982;40:240–244. 9. Aleinikov A, Jordan RCK, Main JHP. Topical steroid therapy in oral lichen planus: Review of a novel delivery method in 24 patients. J Can Dent Assoc 1996 62:324–327. 10. Lodi G, Scully C, Carrozzo M, Griffiths M, Sugerman PB, Thongprasom K. Current controversies in oral lichen planus: Report of an international consensus meeting. Part 2. Clinical management and malig-
ACKNOWLEDGMENTS
nant transformation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:164–178. 11. Choonhakarn C, Busaracome P, Sripanidkulchai B,
The authors thank Professor Dr Laxman Rao, Sri Vishnu Pharmacy College, for his help and concern in the preparation of the aloe vera gel. They would also like to acknowledge the support of Drs N. Vijaya Laxmi, L. A. Swapna, C.H. Saikiran, K. Ramya, and N. Saimadavi.
Sarakarn P. The efficacy of aloe vera gel in the treatment of oral lichen planus: A randomized controlled trial. Br J Dermatol 2008;158:573–577. 12. Vogler BK, Ernst E. Aloe vera: A systemic review of its clinical effectiveness. Br J Gen Pract 1999;49:823–828. 13. Smith S, Jindal R, Singh S. Aloe vera: Boon to dentistry. Indian Dent Res Rev 2010;138–141. 14. Surjushe A, Vasani R, Saple DG. Aloe vera: A short
REFERENCES
review. Indian J Dermatol 2008;53:163–166. 15. Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing oral and topical activity of aloe vera. J Am
1. Amerikanou
CP,
Markopoulos
AK,
Belazi
M,
Ped Med Assoc 1989;79:559–562.
Karamitsos D, Papanayotou P. Prevalence of oral
16. Sampath Kumar KP, Bhowmik D, Chiranjib L, Biswajit
lichen in diabetes mellitus according to the type of
M. Aloe vera: A potential herb and its medicinal importance. J Chem Pharm Res 2010;2:21–29.
diabetes. Oral Dis 1998;4:37–40. 2. Colquhoun AN, Ferguson MM. An association
17. Hayes SM. Lichen planus—Report of successful
between oral lichen planus and a persistently dry
treatment with aloe vera. Gen Dent 1999;47:268–272.
mouth. Oral Surg Oral Med Oral Pathol Oral Radiol
18. Salazar-Sánchez N, López-Jornet P, Camacho-
Endod 2004;98:1–8.
Alonso F, Sanchez-Siles M. Efficacy of topical aloe
3. Vas dis ML, Parks ET. Prevalence of oral lichen planus
vera in patients with oral lichen planus: A random-
in patients with diabetes mellitus. Oral Surg Oral Med
ized double-blind study. J Oral Pathol Med 2010; 39:735–740.
Oral Pathol Oral Radiol Endod 1995;79:696–700. 4. Roopashree MR, Gondhalekar RV, Shashikanth MC,
19. Davis RH, Joseph JD, Donato D, Hartman GM, Haas
George J, Thippeswamy SH, Shukla A. Pathogenesis
RC. Inflammatory and Wound Healing Action of Aloe
of oral lichen planus—A review. J Oral Pathol Med
Vera. Hightstown: Mettler Instrument, 1994:77–81.
2010;39:729–734. 5. Burket S. Oral Medicine, ed 11. Hamilton: BC Decker, 2008.
800
VOLUME 43 t /6.#&39 t 0$50#&3 2012
