Reduced airway hyperresponsiveness by phosphodiesterase 3 ... - NCBI

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Key words: Selective phosphodiesterase inhibitor, Guinea- pig, Airway hyperresponsiveness. Introduction. Bronchial asthma is a disease characterized by varia-.
Research Paper Mediators of Inflammation, 8, 153–157 (1999)

TH E aim o f the pr e s en t s tudy w as to co m p ar e the effe cts o f s elective p h o s p h o dies ter as e (PDE) 3, 4 and 5 in h ibito rs on antigen -in duced airw ay h yp err e s p on s ive ne s s in s en s itized guin ea-pigs . Wh en the s e ns itized guin ea-p igs w er e orally p re -tre ated w ith the s e lective PDE4 in h ibitor, Ro 20–1724 (30 m g/kg), an d s tudied 48 h after OA, a s ign ifican t re duction (P