renal transplantation. clinical - 2

3 downloads 0 Views 28KB Size Report
Oct 7, 2017 - CALCIFICATION AND SERUM FETUIN-A LEVELS IN RENAL. TRANSPLANT RECIPIENTS. Ismail Kocyigit1, Aydin Unal1, Deniz Elcik2, Hafsa ...
Nephrology Dialysis Transplantation 30 (Supplement 3): iii634–iii661, 2015 doi:10.1093/ndt/gfv202.58

RENAL TRANSPLANTATION. CLINICAL - 2 SP832

THE ASSOCIATION BETWEEN CARDIAC VALVULAR CALCIFICATION AND SERUM FETUIN-A LEVELS IN RENAL TRANSPLANT RECIPIENTS

Ismail Kocyigit1, Aydin Unal1, Deniz Elcik2, Hafsa Korkar3, Ahmet Sen4, Mustafa Yasan2, Eray Eroglu3, Murat Hayri Sipahioglu1, Bulent Tokgoz1 and Oktay Oymak1 1 Erciyes University Medical School, Nephrology, Kayseri, Turkey, 2Erciyes University Medical School, Cardiology, Kayseri, Turkey, 3Erciyes University Medical School, Internal Medicine, Kayseri, Turkey, 4Erciyes University Medical School, Biochemistry, Kayseri, Turkey Introduction and Aims: The presence of cardiac valvular calcification in patients with chronic kidney disease has become important recently. We aimed to evaluate the prevalence of cardiac valvular calcification and its association with serum Fetuin-A

levels in kidney transplant recipients. Methods: The cardiac valvular calcification was assessed by echocardiography in 89 kidney transplant recipients. Serum Fetuin-A levels were measured by the enzyme-linked immunosorbent assay (ELISA) method. Results: Patients were divided into 3 groups; patients without cardiac valvular calcification (n: 14), patients with aortic valve calcification (n: 51) and patients with both aortic and mitral valvecalcification (n: 24). Aortic calcification area and number of aortic calcification were significantly increased in patients with aortic and mitral calcification group than other two groups. These two parameters were also significantly increased in patients with cardiac valvular calcification than patients without cardiac valvular calcification. Serum Fetuin-A levels were significantly increased in patients with aortic valve calcification than other two groups whereas there were no significant differences between these two groups. Serum Fetuin-A levels were positively correlated with blood urea nitrogen (BUN) level (r:0.241, p: 0.025) and serum creatinine level (r: 0.262, p: 0.014) whereas it was negatively correlated with serum phosphorus level (r:-0.409, p: