Particle and Fibre Toxicology
BioMed Central
Open Access
Research
Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: experimental controlled study Ingeborg M Kooter1, A John F Boere1, Paul HB Fokkens1, Daan LAC Leseman1, Jan AMA Dormans2 and Flemming R Cassee*1 Address: 1Centre for Environmental Health Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands and 2Laboratory of Toxicology, Pathology and Genetics, National Institute for Public Health and the Environment, Bilthoven, The Netherlands Email: Ingeborg M Kooter -
[email protected]; A John F Boere -
[email protected]; Paul HB Fokkens -
[email protected]; Daan LAC Leseman -
[email protected]; Jan AMA Dormans -
[email protected]; Flemming R Cassee* -
[email protected] * Corresponding author
Published: 15 May 2006 Particle and Fibre Toxicology 2006, 3:7
doi:10.1186/1743-8977-3-7
Received: 31 January 2006 Accepted: 15 May 2006
This article is available from: http://www.particleandfibretoxicology.com/content/3/1/7 © 2006 Kooter et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract Background: Many epidemiological studies have shown that mass concentrations of ambient particulate matter (PM) are associated with adverse health effects in the human population. Since PM is still a very crude measure, this experimental study has explored the role of two distinct size fractions: ultrafine (
