S1 Fig. - PLOS

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C. B. Setdb11lox/+/Zp3-Cre+. Zp3-Cre+. Setdb11lox/+. Setdb1 KO. Control. Zp3-Cre+. Zp3-Cre+. Setdb12lox/2lox. Setdb12lox/+. Setdb12lox/1lox. Setdb12lox/+.
A

ATG   1  

Setdb1  locus  

TAG  

2  

16   F1  

Targeted  allele   (Setdb13lox)  

F2   R1  

1  

2  

16  

Condi>onal  allele   1   (Setdb12lox)  

2  

16   F1  

Null  allele   (Setdb11lox)  

1  

22   R1  

Zp3-Cre+

Setdb12lox/2lox

Setdb11lox/+/Zp3-Cre+

Setdb12lox/+ Zp3-Cre-

Setdb12lox/1lox Zp3-Cre-

Setdb12lox/+ Zp3-Cre+

200-

Marker

Control

bp 850- 650- 500- 400- 300-

22  

2  

Setdb11lox/+

C

Setdb12lox/1lox Zp3-Cre+ Setdb1 KO

2lox/+ 2lox/1lox 2lox/+ 2lox/1lox Cre- Cre- Cre+ Cre+ 1

22  

IRES-­‐βGeo  

F2   R1  

F1  

B

22  

2

3

4

5

6

7

8 1lox (478 bp) 2lox (403 bp) Cre (367 bp) WT (249 bp)