Serum lipoproteins during antihypertensive ... - Wiley Online Library

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followed up to 42 months after starting therapy. ... significantly (p
Clin. Cardiol. 10, 94-98 (1987)

Serum Lipoproteins During Antihypertensive Therapy with Beta Blocken and Diuretics: A Controlled Long-Term Comparative Trial M . MIDDIXE.

MD.,

P.

WEISWlJILER. M . D . .

P. SCHWANDT. M.D.. H . HOLZGREVE, M D.

Medical Policlinic and Medical Clinic 11, University of Munich, Munich, Federal Republic of West Gennany

Summary: The influence of hydrochlorothiazide and ;itenolol o n serum lipoprotcins was investigated in a randomized. prospective study on 68 men with essential hypertension. Cholesterol, high density lipoprotein (HDL) cholesterol. low density lipoprotein (LDH) cholesterol, triglycerides, and the apolipoproteins A1 and B were followed up to 42 months after starting therapy. Following atcnolol scrum (HDL) cholesterol decreased and serum triglycerides increased significantly (p 100 mg

42.4 f9.9 43.0k11.3

41.5+ 11.7 38.2k8.1"

39.4f8.9 38.Ok9.9"

39.3k 10.2 36.9+ 10.3'

5100 mg > 100 mg

156_+60 158k66

1Y6+ 142 237 f 132"

220k 119 19% 109

170+SY 241 +98'

5 5 0 ing > S O mg

230k43 233 k 4 3

231+23 241 +59

247+44 25 1 +48

241 _+46 254+48

5.50 m g > S O mg

154+33 158_+43

1SOk29 164+S7

168k40 16S+48

161 +42 174+3S

5 5 0 rng

155+60

>SO mg

160+88

180+74 171_+87

176+52 203 _+ 108

189+79 220 86

Months

'

36

HDL cholesterol (mg/d I) Atcncdol

Trig1ycerides (nig/dl) Atenolol Cholesterol (mgidl) Hydrochlomthiazide LDL cholesterol (mg/dl) Hydrochlorothiazide Triglycerides (mg/dl) Hydmchlorothiazide

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