A study on the formation of the nitro radical anion by ornidazole and its significant decrease in a structurally characterized binuclear Cu(II)-complex: impact in biology by Ramesh Chandra Santra, Durba Ganguly, Jyotsna Singh, Kasturi Mukhopadhyay, Saurabh Das
Figure S1: Hydrogen bonding interactions in [Cu2(OAc)4(Onz)2]. Only the relevant hydrogen atoms are shown.
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Figure S2: I R spectrum of Ornidazole
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Figure S3: I R spectrum of [Cu2(OAc)4(Onz)2]
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Figure S4: EPR spectrum of [Cu2(OAc)4(Onz)2]
Figure S5: Cyclic voltammogram of 250 μM Onz and [Cu2(OAc)4(onz)2] at scan rate 0.1 V/sec in aqueous medium at pH = 7.4.
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(Vs-1)1/2 Fig. S6 Dependence of cathodic peak current on square root of scan rate for the reduction of onz (■) and [Cu2(oac)4(onz)2] (●) in pure methanol; T = 25 °C.
Fig. S7 Cyclic voltammograms for [Cu2(OAc)4(Onz)2] in the absence (1) and presence of different concentrations of c t DNA, 70.55 µM (2), 140.64 µM (3), 279.43 µM (4), 618.55 µM (5), 946.87 µM (6), 1783.26 µM (7). [Cu2(OAc)4(Onz)2] = 250 µM; [NaCl] = 120 mM; pH= 7.4; T = 25○C.
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Fig. S8 Double reciprocal plots for the interaction of onz (A) and [Cu2(OAc)4(Onz)2] (B) with c t DNA; [Onz] = [Cu2(OAc)4(Onz)2] = 250 µM, [NaCl] = 120 mM; pH= 7.4; T = 25○C.
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Fig. S9 Plot of normalized increase of peak current as a function of mole-ratio of c t DNA to Onz (A) and [Cu2(OAc)4(Onz)2] (B) respectively. [Onz] = [Cu2(OAc)4(Onz)2] = 250 µM, [NaCl] = 120 mM; pH= 7.4; T = 25○C.
