... which serves as an upper bound for this data. The grey line is plotted for reference to show the relationship predicted by the Ross-Macdonald model assuming ...
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Supplementary Figure S1: The annual FOI and transmission efficiency estimated from crosssectional PR surveys. a) The estimated annual FOI and b) transmission efficiency plotted vs. the log of EIR. Each letter represents a single study from Supplementary Table S2. When several estimates of the EIR or the FOI were reported, a “spider” was plotted with its center at the arithmetic mean and legs that connect the center to each one of the estimates. The solid blue line shows a good fit to the data using equation 2, plotted with b = 0.57, α = 4.6, and t = 43 days. The dashed blue line was drawn with longer times and much higher degrees of heterogeneous biting (i.e. with α = 10, and t = 60 days). Also plotted in red is the heterogeneous biting model fitted to the synthetic cohort study, which serves as an upper bound for this data. The grey line is plotted for reference to show the relationship predicted by the Ross-Macdonald model assuming b = 0.55.
Supplementary Table S1: The outcome of experimental challenge to the bites of a variable number of infectious mosquitoes. Shaded lines give the totals for each number of bites reported, and when multiple studies reported trials with the same number of bites, the separate sources are all listed. The lines marked with an asterisk (*) were resolved beyond the numbers reported in the papers 57,66 through personal correspondence, as described in Supplementary Note 1. The number of infectious bites varied over the course of more than twenty years of experiments; it is now commonly done with five infectious bites. The columns report the number of bites, the total number of people who were challenged with that number of infectious bites, the number of those who became infected, and the source of the information.
