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Pharmacoeconomics 2008; 26 (11): Supplementary Material

ORIGINAL RESEARCH ARTICLE

1170-7690/08/011-0001/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.

Economic Impact and Long-Term Graft Outcomes of Mycophenolate Mofetil Dosage Modifications Following Gastrointestinal Complications in Renal Transplant Recipients Gerardo Machnicki,1 Jean-Francois Ricci,2 Daniel C. Brennan3 and Mark A. Schnitzler4 1 2 3 4

Novartis Pharmaceuticals, East Hanover, New Jersey, USA Novartis Pharma AG, Basel, Switzerland Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA Center for Outcomes Research, Saint Louis University School of Medicine, St. Louis, Missouri, USA

Supplementary Material This supplementary material contains the information referred to in the full version of this article, which can be found at http://pharmacoeconomics.adisonline.com

1

Table AI:

Baseline characteristics at time of first diagnosis of gastrointestinal

complications according to maximum subsequent reduction in MMF dose (NC, no modification to MMF dose; DR, MMF dose reduction; DC, MMF discontinued.) Figures in parentheses indicate percentage of patients in each group. Variable

All patients n=3,589, (100%)

MMF No Change n=2,230, (62.1%)

MMF Dose reduced =50% n=348 (9.7%)

MMF Discontinued n=764 (21.3%)

value 0.12

Age 18-29

416 (11.6)

258 (11.6)

22 (8.9)

44 (12.6)

92 (12)

30-44

1092 (30.4)

697 (31.2)

85 (34.4)

84 (24.2)

226 (29.6)

45-59

1309 (36.5)

797 (35.7)

98 (39.7)

134 (38.5)

280 (36.6)

60 +

772 (21.5)

478 (21.4)

42 (17)

86 (24.7)

166 (21.7) 0.29

Female gender No

2062 (57.4)

1287 (57.7)

150 (60.7)

206 (59.2)

419 (54.8)

Yes

1527 (42.5)

943 (42.3)

97 (39.3)

142 (40.8)

345 (45.2) 0.03

Racial Background Black

1108 (30.9)

653 (29.3)

92 (37.2)

113 (32.5)

250 (32.7)

Other

164 (4.6)

110 (4.9)

15 (6.1)

12 (3.4)

27 (3.5)

White

2317 (64.6)

1467 (65.8)

140 (56.7)

223 (64.1)

487 (63.7) 0.02

Body Mass Index Normal

1054 (29.4)

653 (29.3)

64 (25.9)

90 (25.9)

247 (32.3)

Overweight

712 (19.8)

415 (18.6)

60 (24.3)

74 (21.3)

163 (21.3)

Obese

512 (14.3)

318 (14.3)

31 (12.5)

64 (18.4)

99 (13)

Unknown

1311 (36.5)

844 (37.8)

92 (37.2)

120 (34.5)

255 (33.4)

Functional Limitations No

P

0.85

3348 (93.3)

2079 (93.2)

233 (94.3)

322 (92.5)

714 (93.5)

2

Yes

241 (6.7)

151 (6.8)

14 (5.7)

26 (7.5)

50 (6.5) 0.71

Previous pregnancies No

2634 (73.4)

1639 (73.5)

184 (74.5)

261 (75)

550 (72)

Yes

955 (26.6)

591 (26.5)

63 (25.5)

87 (25)

214 (28) 0.18

Primary Cause of ESRD Type I diabetes

463 (12.9)

299 (13.4)

27 (10.9)

53 (15.2)

84 (11)

Type II diabetes

539 (15)

351 (15.7)

26 (10.5)

55 (15.8)

107 (14)

Hypertension

867 (24.2)

528 (23.7)

58 (23.5)

89 (25.6)

192 (25.1)

Glomeruloneprhit is Unknown

454 (12.6)

276 (12.4)

37 (15)

44 (12.6)

97 (12.7)

1266 (35.3)

776 (34.8)

99 (40.1)

107 (30.7)

284 (37.2) 0.07

Pre transplant dialysis No

648 (18.1)

422 (18.9)

52 (21)

56 (16.1)

118 (15.4)

Yes

2941 (81.9)

1808 (81.1)

195 (78.9)

292 (83.9)

646 (84.5)

Recipient comorbidities Angina

0.82

No

3070 (85.5)

1904 (85.4)

215 (87)

294 (84.5)

657 (86)

Yes

519 (14.5)

326 (14.6)

32 (13)

54 (15.5)

107 (14) 0.92

Arryhtmia No

3552 (99)

2205 (98.9)

245 (99.2)

345 (99.1)

757 (99.1)

Yes

37 (1)

25 (1.1)

2 (0.8)

3 (0.9)

7 (0.9) 0.63

Congestive heart failure No

3302 (92)

2044 (91.7)

232 (93.9)

321 (92.2)

705 (92.3)

Yes

287 (8)

186 (8.3)

15 (6.1)

27 (7.8)

59 (7.7) 0.72

COPD No

3523 (98.2)

2185 (98)

244 (98.8)

343 (98.6)

751 (98.3)

Yes

66 (1.8)

45 (2)

3 (1.2)

5 (1.4)

13 (1.7) 0.47

Cerebrovascular

3

disease No

3495 (97.4)

2177 (97.6)

242 (98)

337 (96.8)

739 (96.7)

Yes

94 (2.6)

53 (2.4)

5 (2)

11 (3.2)

25 (3.3) 0.84

Hypertension No

746 (20.8)

454 (20.4)

54 (21.9)

72 (20.7)

166 (21.7)

Yes

2843 (79.2)

1776 (79.6)

193 (78.1)

276 (79.3)

598 (78.3) 0.85

Myocardial infarction No

3539 (98.6)

2197 (98.5)

245 (99.2)

343 (98.6)

754 (98.7)

Yes

50 (1.4)

33 (1.5)

2 (0.8)

5 (1.4)

10 (1.3) 60 minutes No 3475 (96.8)

2161 (96.9)

235 (95.1)

338 (97.1)

741 (97)

Yes

69 (3.1)

12 (4.9)

10 (2.9)

23 (3)

114 (3.2)

0.30

Pretransplant transfusions No

2373 (66.1)

1464 (65.6)

177 (71.7)

228 (65.5)

504 (66)

Yes

1216 (33.9)

766 (34.3)

70 (28.3)

120 (34.5)

260 (34)

Cytomegalovirus sero-pairing Donor/RecipientDonor/Recipient+ Donor+/Recipient Donor+/Recipient + Undiagnosed