Supplementary Table 2 - PLOS

Supplementary Table 2 Biomarker (Category & Name) Astrocytic Activation 72 kDa type IV collagenase (v2) Alpha-‐2 macroglobulin Creatine kinase B-‐type Fibronectin Leukemia inhibitory factor Protein S100-‐B Blood Brain Barrier Platelet-‐derived growth factor subunit A (dimer) Platelet-‐derived growth factor subunit B; AB/BB (dimer) Stromelysin-‐1 (v2) Thrombomodulin (v1) Thrombopoietin von Willebrand Factor Chemokine C-‐C motif chemokine 1 C-‐C motif chemokine 13 (v1) C-‐C motif chemokine 13 (v2) C-‐C motif chemokine 15 C-‐C motif chemokine 17 (v1)

CT 0 1 0 1 0 1 0 1 0 1 0 1

N

Mean

SEM

79 13 79 13 79 13 79 13 79 11 78 13

313233.71 351561.87 1009.86 1004.99 37.27 64.08 295140.80 292506.35 126.74 6.63 3.69 4.56

10094.21 24185.37 42.07 73.26 2.35 13.22 8484.65 21389.62 120.41 4.89 0.64 1.57

0 1 0 1 0 1 0 1 0 1 0 1

79 13 79 13 79 13 79 13 79 11 79 13

1559.87 1057.13 15541.29 7336.68 7350.26 8152.60 1875.25 2058.75 2513.52 810.40 44058.66 53206.09

194.76 207.08 2747.45 1695.75 549.29 1310.20 96.27 368.03 1604.24 806.82 2809.80 5516.92

0 1 0 1 0 1 0 1 0 1

79 11 79 11 79 13 79 11 79 11

6.32 2.39 52.04 16.18 1496.63 1143.84 2316.74 2102.08 40.37 29.85

3.80 0.70 21.70 6.78 113.38 180.15 176.73 432.32 6.12 5.03

Supplementary Table 2, Continued Biomarker (Category & Name) CT C-‐C motif chemokine 17 (v2) 0 1 C-‐C motif chemokine 2 0 1 C-‐C motif chemokine 21 0 1 C-‐C motif chemokine 22 0 1 C-‐C motif chemokine 24 0 1 C-‐C motif chemokine 26 0 1 C-‐C motif chemokine 27 0 1 C-‐C motif chemokine 3 0 1 C-‐C motif chemokine 4 0 1 C-‐C motif chemokine 5 0 1 C-‐C motif chemokine 7 0 1 C-‐C motif chemokine 8 0 1 C-‐X-‐C motif chemokine 10 0 1 C-‐X-‐C motif chemokine 13 0 1 C-‐X-‐C motif chemokine 5 0 1 Eotaxin 0 1 Inflammatory Alpha-‐2-‐HS-‐glycoprotein 0 1 CD40 ligand 0 1 C-‐reactive protein 0 1

N 79 13 79 13 79 11 79 13 79 11 79 11 79 11 79 13 79 13 79 13 79 13 79 11 79 13 79 11 79 11 79 13

Mean 184.34 126.88 1493.77 1733.15 832.51 855.49 878.97 1012.90 434.23 459.33 92.66 6.00 524.08 532.43 22.02 1.34 110.59 89.84 58999.65 27778.33 20.67 9.95 29.91 16.15 1018.58 784.48 68.84 43.40 512.65 348.59 911.15 865.39

SEM 25.28 19.28 114.13 386.11 357.60 359.04 40.19 105.74 43.43 81.99 80.57 3.63 24.76 85.10 13.98 0.70 32.90 29.42 8796.11 5526.00 5.96 5.69 6.13 3.06 183.96 185.13 17.95 6.17 68.36 124.46 48.64 96.04

79 13 79 13 79 13

471240.36 474120.73 2371.46 672.73 6361.67 13573.41

10727.37 22726.58 479.05 177.39 1050.37 4570.67

Supplementary Table 2, Continued Biomarker (Category & Name) CT Fibrinogen (v2) 0 1 Fms-‐related tyrosine kinase 3 ligand Flt-‐3 0 1 Granulocyte-‐macrophage colony-‐stimulating factor 0 1 Haptoglobin 0 1 Intercellular adhesion molecule 1 0 1 Interferon alpha-‐2 0 1 Interferon gamma 0 1 Interleukin-‐1 alpha 0 1 Interleukin-‐1 beta 0 1 Interleukin-‐1 receptor antagonist protein 0 1 Interleukin-‐10 0 1 Interleukin-‐12 0 1 Interleukin-‐13 0 1 Interleukin-‐15 0 1 Interleukin-‐17A 0 1 Interleukin-‐2 0 1 Interleukin-‐2 receptor alpha chain (v2) 0 1 Interleukin-‐20 0 1 Interleukin-‐21 0 1 Interleukin-‐23 0 1

N 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 11 79 11 79 11

Mean 1403.72 1409.11 4.12 1.75 0.47 2.25 336902.47 166404.89 181121.90 173012.84 56.64 40.87 1.17 0.26 28.71 18.26 0.29 0.11 59.64 35.17 8.39 5.10 13.05 0.78 9.31 1.23 7.05 0.51 14.39 6.62 0.22 0.28 40.75 20.52 426.22 66.10 23.50 36.81 2717.92 1438.61

SEM 59.24 168.91 1.98 1.50 0.11 1.71 53786.04 91994.89 6103.88 8377.68 12.24 7.67 0.72 0.10 13.57 15.57 0.17 0.05 22.53 17.61 2.60 1.89 6.97 0.23 6.31 0.71 3.00 0.24 7.54 2.13 0.03 0.08 25.92 14.83 346.05 34.41 18.35 36.43 1666.36 1430.24

Supplementary Table 2, Continued Biomarker (Category & Name) CT Interleukin-‐28A 0 1 Interleukin-‐3 0 1 Interleukin-‐33 0 1 Interleukin-‐4 (v1) 0 1 Interleukin-‐6 0 1 Interleukin-‐7 0 1 Interleukin-‐8 (v2) 0 1 Interleukin-‐8 (v3) 0 1 Interleukin-‐9 0 1 Lymphotoxin-‐alpha 0 1 Matrix metalloproteinase-‐9 (v2) 0 1 Myeloperoxidase 0 1 Neural cell adhesion molecule 1 0 1 Oxidized low-‐density lipoprotein receptor 1 0 1 Pro-‐epidermal growth factor (v2) 0 1 Pro-‐interleukin-‐16 0 1 Thymic stromal lymphopoietin 0 1 Tumor necrosis factor 0 1 Tumor necrosis factor ligand superfamily member 10 0 1

N 79 11 79 13 79 11 79 13 79 13 79 13 79 13 79 13 79 13 79 13 79 13 78 13 79 13 79 13 79 13 79 11 79 11 79 13 79 11

Mean 164.29 5.67 1.59 0.59 221.20 77.55 4.30 0.06 14.43 17.90 4.63 1.06 132.26 281.62 5.29 11.51 3.58 0.23 15.87 0.38 235031.30 378018.03 938.79 1006.30 296602.07 324322.70 0.24 0.30 31.45 12.54 144.50 72.91 345.03 55.98 5.47 6.82 43.82 11.86

SEM 142.34 4.66 0.28 0.24 163.23 77.33 2.31 0.05 3.57 3.46 1.68 0.57 18.54 81.96 0.75 3.45 2.52 0.12 10.20 0.36 25362.21 97822.26 36.60 94.68 10229.95 18880.36 0.03 0.05 6.83 3.65 52.54 16.23 237.55 54.54 0.36 1.19 15.84 2.74

Supplementary Table 2, Continued Biomarker (Category & Name) Oxidative Stress Amyloid beta A4 protein (fragment AB40; Amyloid Beta 40) Amyloid beta A4 protein (fragment AB42; Amyloid Beta 42) Apolipoprotein(a) Fatty acid-‐binding protein, heart Malondialdehyde-‐modified low-‐density lipoprotein Neuronal Injury Brain-‐derived neurotrophic factor Cathepsin D Glial cell line-‐derived neurotrophic factor Heparin-‐binding growth factor 2 (v2) Kit ligand Natriuretic peptides B Serum amyloid P-‐component

CT

N

0 1

79 13

64.84 77.38

3.73 15.23

0 1 0 1 0 1 0 1

79 13 79 13 79 13 79 13

32.54 27.80 92814.19 94565.43 1.24 8.43 580.42 161.65

1.64 2.57 11897.85 15866.39 0.39 6.84 192.08 38.70

0 1 0 1 0 1 0 1 0 1 0 1 0 1

79 13 79 13 78 13 79 13 79 11 79 13 79 13

3363.81 1749.10 171448.62 169165.47 2.30 0.64 143.13 63.69 83.47 21.90 886.43 2460.24 9700.67 8096.09

475.78 345.09 14238.51 19739.43 1.27 0.25 35.38 13.50 53.99 6.65 313.58 1500.54 361.13 1041.52

Mean

SEM

Supplementary Table 2 - PLOS

Supplementary Table 2 - PLOS

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