Supporting Information Construction of A Triple-Stimuli-Responsive System Based on Cerium Oxide Coated Mesoporous Silica Nanoparticles
Jia Wen 1, Kui Yang 1, Yongqian Xu 1, Hongjuan Li 1, Fengyu Liu2,* and Shiguo Sun1,* 1
Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Science, Northwest
A&F University, Yangling, Shaanxi 712100, People’s Republic of China 2
State Key Laboratory of Fine Chemicals, School of Chemistry, Dalian University of Technology,
No.2 linggong Road, Ganjingzi, District, Dalian 116023, People’s Republic of China
*Corresponding author: Fengyu Liu (
[email protected]) Shiguo Sun (
[email protected])
Table of contents
Fig. S1 ....................................................................................................................................... 2 Fig. S2 ....................................................................................................................................... 2 Fig. S3 ....................................................................................................................................... 3 Fig. S4 ....................................................................................................................................... 3 Fig. S5 ....................................................................................................................................... 4 Fig. S6 ....................................................................................................................................... 5 Fig. S7 ....................................................................................................................................... 5
1
Fig. S1
Fig. S1 SEM micrographs of (a) MSN-HP and (b) MSN-HP-DOX.
Fig. S2
Fig. S2 HRTEM micrographs of (a) MSN-HP and (b) MSN-HP-DOX.
2
Fig. S3
Fig. S3 EDX spectrum of (a) MSN; (b) MSN-HP ; (c) MSN-HP-DOX; (d) MSN-HP-DOX@CeO2.
Transmittance (%)
Fig. S4
MSN MSN-HP-DOX@CeO2
4000
3500
3000
2500
2000
1500
1000
500
Wavenumber (cm-1)
Fig. S4 FTIR spectra of MSN and MSN-HP-DOX@CeO2.
3
Fig. S5
0.5
b) 0.5
0.4
0.4
Absorbance
Absorbance
a)
0.3 0.2 0.1
0.3 0.2 0.1
0.0 300
400
500
600
0.0 300
700
400
c) 0.5
d)
Absorbance
Absorbance
0.4 0.3 0.2
700
0.5 0.4 0.3 0.2
0.0
0.0 300
400
500
600
300
700
400
0.5
f)
600
700
1.5 1.2
Absorbance
0.4 0.3 0.2 0.1
0.9 0.6 0.3
0.0 300
500
Wavelength (nm)
Wavelength (nm)
Absorbance
600
0.1
0.1
e)
500
Wavelength (nm)
Wavelength (nm)
400
500
600
0.0 200
700
Wavelength (nm)
300
400
500
600
700
Wavelength (nm)
Fig. S5 Absorbance spectrum of MSN (a), MSN-HP (b), MSN-HP-DOX (c), MSN-HP-DOX@CeO2 (d), HP (e) and DOX (f).
4
Fig. S6 400
300
200
100
0 550
600
650
800
b)
A B C D E
Fluorescence Intensity (a.u.)
Fluorescence Intensity (a.u.)
a)
A B
600
400
200
700
0 500
550
Wavelength (nm)
Fig. S6
600
650
700
Wavelength (nm)
(a) Emission spectra of MSN-HP (A), MSN-HP-DOX (B), MSN-HP -DOX with the addition of GSH (C),
MSN-HP-DOX@CeO2 without the addition of GSH and irradiation (D), MSN-HP-DOX@CeO2 with the addition of GSH and irradiation (E) λex = 480 nm. (b) Emission spectra of HP (A) and DOX (B) λex = 480 nm.
Fig. S7
Absorption
0.3
0.2 laser
0.1
0.0 300
400
500
600
700
800
Wavelength (nm) Fig. S7 Determination of the generation of singlet oxygen of MSN-HP-DOX@CeO2 through the absorption of DPBF upon irradiation by laser at 633 nm for 0 min, 5 min, 10 min, 15 min, 20 min, 25 min, 30 min, 35 min, 40 min, 45 min, 50 min, 55 min, 60 min, 70 min, 80 min, 90 min and 120 min).
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