J Gastrointest Surg (2011) 15:1670–1678 DOI 10.1007/s11605-011-1643-2
2011 SSAT POSTER PRESENTATION
Systemic Inflammation with Multiorgan Dysfunction Is the Cause of Death in Murine Ligation-Induced Acute Pancreatitis Zuobiao Yuan & David K. Meyerholz & Erik C. Twait & Duraisamy Kempuraj & Deborah E. Williard & Isaac Samuel
Received: 17 May 2011 / Accepted: 13 July 2011 / Published online: 29 July 2011 # 2011 The Society for Surgery of the Alimentary Tract
Abstract Background We have previously shown that distal pancreatic duct ligation-induced acute pancreatitis in mice is associated with substantial mortality. Methods We examined the cause of death in duct ligation-induced acute pancreatitis in mice by serial examination of multiple parameters in three experimental groups: distal pancreatic duct ligation (PD), bile duct ligation alone (BD), and sham operation (S). Results BD and S had no mortality, while PD had 94% mortality with most deaths between days 2 and 4. Characteristics of mice with acute pancreatitis included (ANOVA; p
