Legend: Sd. Error, standard error; RDW, red blood cell distribution width; Î, adjusted delta (discharge- admission/admission*100); BNP, brain natriuretic peptide.
Supplemental Table 1. Characteristics of the study population globally and according to RDW changes (Paris cohort) Total (n=332) ΔRDW ≤0 (n=209) ΔRDW >0 (n=123) Variables P-value % missing values Demographics and history Age (years) 76.4 ± 12.2 76.0 ± 12.1 76.9 ± 12.4 0.519 0 Male sex – n. (%) 184 (55.4) 117 (56.0) 67 (54.5) 0.789 0 Hypertension – n. (%) 234 (70.5) 148 (70.8) 86 (69.9) 0.863 0 Diabetes mellitus – n. (%) 96 (28.9) 61 (29.2) 35 (28.5) 0.887 0 COPD – n. (%) 43 (13.0) 19 (9.1) 24 (19.5) 0 0.006 AFib – n. (%) 139 (41.9) 80 (38.3) 59 (48.0) 0.084 0 Heart Failure characterization Ischemic etiology – n. (%) 131 (39.5) 81 (38.8) 50 (40.7) 0.733 0 LVEF (%) 41.9 ± 16.0 41.4 ± 14.9 42.8 ± 17.9 0.530 27.1 LVEF 15 and ΔRDW >0 (n=63). Model 1, adjusted for sex and age; Model 2, adjusted for sex, age, atrial fibrillation, admission hemoglobin and BNP. No statistically significant interactions were found between the interest and explanatory variables. Bold, significant value (p≤0.05). Legend: HR, hazard ratio; RDW, red blood cell distribution width; Δ, adjusted delta (discharge-admission/admission*100); BNP, brain natriuretic peptide.
Supplemental Table 5. Net reclassification improvement and integrated discrimination improvement for predicting All-Cause Mortality at 180 days (Paris cohort) Added variable(s) Baseline set of variables NRI (%) P-value IDI (%)
P-value
Discharge RDW (continuous) on top of age, LVEF, Hb, pCr and NT-pro BNP 27.5 (-8.9 to 43.2) 0.086 1.4 (-1.0 to 10.3) 0.239 Discharge RDW >15% 25.2 (-2.1 to 40.8) 0.073 2.5 (-0.2 to 11.6) 0.126 ΔRDW >0 18.2 (-7.2 to 33.2) 0.106 2.2 (-0.5 to 8.2) 0.139 Discharge RDW >15% and ΔRDW >0 19.3 (3.4 to 42.7) 3.5 (0.4 to 12.2) 0.020 0.013 The prediction models include the following variables dichotomized according to the median: age in years (0 ΔRDW ≤0 and ΔHemoglobin >0
5.65 (2.49 – 12.80) Reference
0
2.31 (0.73 – 7.27)
0.241
2.04 (0.64 – 6.52)
0.229
1.77 (0.54 – 5.74)
0.344
ΔRDW >0 and ΔHemoglobin ≤0 2.10 (0.88 – 5.03) 0.096 2.06 (0.86 – 4.95) 0.104 4.42 (1.76 – 11.02) 0.002 RDW discharge ≤15% and ΔRDW ≤0 (n=77); RDW discharge ≤15% and ΔRDW >0 (n=26); RDW discharge >15 and ΔRDW ≤0 (n=26); RDW discharge >15 and ΔRDW >0 (n=32). ΔRDW ≤0 and ΔHemoglobin >0 (n=34); ΔRDW ≤0 and ΔHemoglobin ≤0 (n=68); ΔRDW >0 and ΔHemoglobin >0 (n=11); ΔRDW >0 and ΔHemoglobin ≤0 (n=47). ΔHemoglobin >0 = hemoconcentration i.e. increase in hemoglobin from admission to discharge, and ΔHemoglobin ≤0 = no hemoconcentration i.e. decrease or no increase in hemoglobin from admission to discharge Model 1, adjusted for sex and age; Model 2, adjusted for sex, age, atrial fibrillation, admission hemoglobin and NT-pro BNP.
No statistically significant interactions were found between the interest and explanatory variables. Bold, significant value (p≤0.05). Legend: HR, hazard ratio; RDW, red blood cell distribution width; Δ, adjusted delta (discharge-admission/admission*100); NT-pro BNP, N-terminal pro brain natriuretic peptide.
Table 7. Net reclassification improvement and integrated discrimination improvement for predicting All-Cause Mortality at 180 days (Porto cohort) Added variable(s) Baseline set of variables NRI (%) P-value
IDI (%)
P-value
Discharge RDW (continuous) on top of age, LVEF, Hb, pCr and NT-pro BNP 34.7 (-2.0 to 50.0) 0.073 8.4 (1.1 to 19.6) 0.020 Discharge RDW >15% 35.6 (3.6 to 55.1) 7.5 (1.0 to 20.6) 0.040 0.007 ΔRDW >0 37.2 (6.0 to 55.4) 7.4 (1.0 to 19.0) 0.020 0.013 Discharge RDW >15% and ΔRDW >0 31.9 (17.6 to 47.1) 12.6 (3.5 to 27.3) 0 (hemoconcentration) 2.7 (-9.3 to 23.0) 1.000 0.1 (-0.2 to 4.5) 0.292 The prediction models include the following variables dichotomized according to the median: age in years (
