RESEARCH ARTICLE
The Coupling of Peripheral Blood Pressure and Ventilatory Responses during Exercise in Young Adults with Cystic Fibrosis Erik H. Van Iterson1*, Courtney M. Wheatley1,2, Sarah E. Baker2,3, Thomas P. Olson1, Wayne J. Morgan4, Eric M. Snyder2,5
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1 Department of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, United States of America, 2 College of Pharmacy, University of Arizona, 1295 N Martin Ave, Tucson, AZ, United States of America, 3 Department of Anesthesiology, Mayo Clinic, Rochester, MN, United States of America, 4 Department of Pediatrics, University of Arizona, 1501 N. Campbell Avenue, Room 3301, Tucson, AZ, United States of America, 5 Department of Kinesiology, University of Minnesota, Cooke Hall, 1900 University Ave SE. Minneapolis, MN, United States of America *
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Abstract OPEN ACCESS Citation: Van Iterson EH, Wheatley CM, Baker SE, Olson TP, Morgan WJ, Snyder EM (2016) The Coupling of Peripheral Blood Pressure and Ventilatory Responses during Exercise in Young Adults with Cystic Fibrosis. PLoS ONE 11(12): e0168490. doi:10.1371/journal.pone.0168490 Editor: Germa´n E. Gonza´lez, Universidad de Buenos Aires, ARGENTINA Received: June 26, 2016 Accepted: November 30, 2016 Published: December 20, 2016 Copyright: © 2016 Van Iterson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All individuals who participated in this study provided written informed consent prior to study participation. Individuals consented to having results from this study presented in published format as mean values of the sample as demonstrated in this manuscript. However, this consent did not include a provision stating that individual raw data would be made freely and fully publicly available at a later time. Therefore, without this additional consent of individuals to have their individual raw data made fully publicly available, it goes against the policy of
Purpose Cystic fibrosis (CF) is commonly recognized as a pulmonary disease associated with reduced airway function. Another primary symptom of CF is low exercise capacity where ventilation and gas-exchange are exacerbated. However, an independent link between pathophysiology of the pulmonary system and abnormal ventilatory and gas-exchange responses during cardiopulmonary exercise testing (CPET) has not been established in CF. Complicating this understanding, accumulating evidence suggests CF demonstrate abnormal peripheral vascular function; although, the clinical implications are unclear. We hypothesized that compared to controls, relative to total work performed (WorkTOT), CF would demonstrate increased ventilation accompanied by augmented systolic blood pressure (SBP) during CPET.
Methods 16 CF and 23 controls (age: 23±4 vs. 27±4 years, P = 0.11; FEV1%predicted: 73±14 vs. 96±5, _ 2 ), ventilation (V_ E ), and P
