The effect of acute intraocular pressure elevation on peripapillary ...

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retardance. Brad Fortune1, Hongli Yang1,B, Nicholas G. Strouthidis1,B, Grant A. Cull1, Jonathan L. Grimm1,B, J. Crawford Downs1,C, and Claude F. Burgoyne.
NIH Public Access Author Manuscript Invest Ophthalmol Vis Sci. Author manuscript; available in PMC 2010 October 1.

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Published in final edited form as: Invest Ophthalmol Vis Sci. 2009 October ; 50(10): 4719–4726. doi:10.1167/iovs.08-3289.

The effect of acute intraocular pressure elevation on peripapillary retinal thickness, retinal nerve fiber layer thickness and retardance Brad Fortune1, Hongli Yang1,B, Nicholas G. Strouthidis1,B, Grant A. Cull1, Jonathan L. Grimm1,B, J. Crawford Downs1,C, and Claude F. Burgoyne1,B 1Discoveries in Sight Research Laboratories, Devers Eye Institute, Legacy Health System, Portland, OR, USA BOptic

Nerve Head Research Laboratory

COcular

Biomechanics Laboratory

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Abstract Purpose—To determine whether acutely elevated intraocular pressure (IOP) alters peripapillary retinal thickness, retinal nerve fiber layer thickness (RNFLT) or retardance. Methods—Nine adult non-human primates were studied under isoflurane anesthesia. Retinal and RNFL thicknesses were measured by spectral domain optical coherence tomography 30 min after IOP was set to 10 mmHg and 60 min after IOP was set to 45 mmHg. RNFL retardance was measured by scanning laser polarimetery in 10 min intervals for 30 min while IOP was 10 mmHg, then for 60 min while IOP was 45 mmHg, then for another 30 min after IOP was returned to 10 mmHg.

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Results—RNFLT measured 1120 μm from the ONH center decreased from 118.1 ± 9.3 μm at an IOP of 10 mmHg to 116.5 ± 8.4 μm at 45 mmHg, or by 1.4 ± 1.8% (p