RESEARCH ARTICLE
The impact of acute kidney injury on inhospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis Florica Gadalean1☯, Mihaela Simu2☯, Florina Parv3*, Ruxandra Vorovenci2, Raluca Tudor2, Adalbert Schiller1, Romulus Timar4, Ligia Petrica1, Silvia Velciov1, Cristina Gluhovschi1, Flaviu Bob1, Adelina Mihaescu1, Bogdan Timar5, Goce Spasovski6, Viviana Ivan3
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OPEN ACCESS Citation: Gadalean F, Simu M, Parv F, Vorovenci R, Tudor R, Schiller A, et al. (2017) The impact of acute kidney injury on in-hospital mortality in acute ischemic stroke patients undergoing intravenous thrombolysis. PLoS ONE 12(10): e0185589. https://doi.org/10.1371/journal.pone.0185589 Editor: Pasqual Barretti, Universidade Estadual Paulista Julio de Mesquita Filho, BRAZIL Received: May 13, 2017 Accepted: September 17, 2017 Published: October 17, 2017 Copyright: © 2017 Gadalean et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability Statement: All relevant raw data used in this study can be downloaded from https:// doi.org/10.6084/m9.figshare.5433250.v1. Funding: This research project was funded by an internal grant from the University of Medicine and Pharmacy ‘‘Victor Babes’’ Timisoara, PIII-C2-PCFI2015/2016, www.umft.ro. AS received the funding. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
1 Department of Nephrology, County Emergency Hospital Timisoara, Romania, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, Romania, 2 Department of Neurology, County Emergency Hospital Timisoara, Romania, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, Romania, 3 Department of Cardiology, County Emergency Hospital Timisoara, Romania, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, Romania, 4 Department of Diabetes and Metabolic Diseases, County Emergency Hospital Timisoara, Romania, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, Romania, 5 Department of Bioinformatics, County Emergency Hospital Timisoara, Romania, ‘Victor Babes’ University of Medicine and Pharmacy, Timisoara, Romania, 6 Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Macedonia ☯ These authors contributed equally to this work. *
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Abstract Introduction Acute kidney injury (AKI) increases the risk of death in acute ischemic stroke (AIS) patients. Intravenous thrombolytic therapy (iv. rt-PA) seems to be the most effective treatment for AIS patients. The effects of AKI on iv. rt-PA treated AIS cases is less studied. Our paper addresses this issue.
Methods 45 consecutive stroke patients treated with iv. rt-PA (median age = 64 years; 29 male) and 59 age and sex matched controls not eligible for iv. rt-PA have been enrolled in our study. Subjects were followed-up until hospital release or death (median follow up time = 12 days).
Results The prevalence of AKI did not differ between iv. rt-PA treated patients and controls (35.5% vs. 33.89%). In both groups, AKI was associated with increased in-hospital mortality: 50.0% vs. 3.4% p
