Dec 3, 1991 - A third member of the thrombospondin gene family. (Thbs3) has been ... ation signal of one gene from the start of transcription of the other.
THEJOURNAL OF BIOLOGICAL CHEMISTRY 0 1992 hy The American Society for Biochemistry and Molecular Biology, Inc.
Vol. 267, No. 17,lesue ofJune 15, pp. 12192-12196,1992 Printed in U.S A .
Thrombospondin 3 (Thbs3),a New Member of the Thrombospondin Gene Family* (Received for publication, December 3, 1991)
Hans L. Voss, Sreelekha Devarayalus, Yne de VriesS, and Paul Bornsteinsq From the $Division of Tumor Biology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands and the $Department of Biochemistry, SJ-70, University of Washington, Seattle, Washington 98195
A third member of the thrombospondin gene family In the20 years since its discovery, TSP has been implicated (Thbs3)has been partially characterized in the mouse. in a large number of cellular processes. Platelet TSP clearly Thbs3ITHBS3 gene functions in hemostasis, in part through its involvement in In both the mouse and humans, the is located immediately upstream from MuclIMUCl the the second secretion-dependent phase of platelet aggregation (episialin)gene;
