Translation-new Supp - PLOS

Supplemental Figure 3A Im

in

y ib mc pa a R

n ati

Translation

Rpl24 Eif1 Mrpl16 Mrpl4 Mrpl19 Pa2g4 Eif4a1 Mrps9 Eif2b3 Mrps5 Gfm1 Kars Gfm2 Eif3d Eif2s2 Mrpl24 Yars2 Iars2 Eif3c Eif3g Rps15 Rbm3 Tufm Rpl9 Rps3 Mrpl9 Ptrh1 Rpl29 Eif3i Rps17 Rpl36 Rpl37 Rps18 Eif2s3x Rpl23 Rps11 Rps9 Eif3k Sars Rpl18a Rps7 Eif3h Eef1b2 Eif3e Rpl26 Rpl6 Fxr1 Rpl19 Rps24 Eif2a Rpl8 Eif3m Rpl27a Rpl10 Eef1g Eif3f Rpl4 Eef1d Eef2 Eef1a1

b

ni ati

Ra Im Mitochondria

C1qbp Immp2l Cox5a Dap3 Mrpl16 Ckmt1 Pnpt1 Mrpl19 Atp5b Mosc2 Phb2 Ugt1a6a Msto1 Timm44 Mrpl38 Aifm1 Apool Atp5d Atp5f1 Bckdhb Pmpcb Ndufb5 Vdac2 Atad3a Atp5c1 Oxa1l Bcs1l Acsl4 Mdh2 Tufm Acadl Slc25a4 Atp5a1 Got2 Hadh Hspd1 Uqcrc2 Slc25a17 Ndufs2 Uqcrfs1 Vdac1 Slc25a5 Slc25a3

b

ni ati

Ra Im Nucleus

Clta Napsa Ctsh Ctsc Ctsz Gba Ctsd Ctss Lamp2 Galns Atp6v1h Npc2 Ap4m1

Proteasome

­3

­1

1

Psmb8 Psme1 Psmb3 Psmd4 Psmf1 Psmb1 Psma5

3

PI Signaling

in

cy

m pa

Lysosome

Antigen  Processing Ifi30 Psme1 Tap1 Hspa4 Ctss Canx Pdia3 Hspa8 H2­Oa Hsp90ab1

in

cy

m pa

Abl1 Fancd2 Ncaph2 Bcl6 Stk4/Mst1 Clk4 Qk Rcor1 Zeb2 Clk1 Ezh2 Pou2f1 Son Chek2 Afmid Lef1 Mef2a Tcf12 Foxp1 Ssbp2 Triobp Usp11 Sesn3 Setd8 Rnf34 Sfmbt1 Zfp238 Foxn3 Atf2 Irf1 Cuedc2 Exo1 Lats2 Mapkap1 Bach2 Rnf14 Senp5 Maf1 Zcchc17 Atrx Eif2s1 Cbfb Pde4b Ppp1cb Chfr Ppp3ca Smek2 Depdc1a E2f6 Rfwd3 Rngtt Zzz3 0610007P08Rik Elf2 MafG Calm1 Dgk! Pik3ca Itpkb

Actin  Cytoskeleton Cyfip2/PIR121 Wasf2/WAVE2 Pik3ca Itga4 Ppp1cb Iqgap1

Supplemental Figure 3B

d.

d.

n un tio Ab   a l A ns RN m Tra

n un tio Ab   a l A ns RN m Tra Translation

Antigen  Presentation

Rpl24 Fxr1 Eif2a Eif3f Mrps9 Rps9 Rpl10 Rpl27a Mrpl9 Rpl36 Rpl9 Eif3h Rpl26 Rps7 Rpl37 Eef1a1 Rps3 Eef2 Eif3k Rps15 Rpl19 Rps17 Eef1b2 Iars2 Rps11 Rps24 Rpl4 Eif3m Eif3e Eif1 Ptrh1 Rbm3 Rpl23 Gfm2 Sars Rpl18a Mrpl4 Eif3c Eif3d Rpl6 Kars Eef1d Eif3g Eif2s2 Tufm Eif3i Gfm1 Mrpl19 Eif2s3x Pa2g4 Rpl8 Eif4a1 Mrpl16 Yars2 Eif2b3

Tap1 H2­Oa Hsp90ab1 Ctss Psme1 Ifi30 Canx Hspa8 Hspa4 Pdia3

Mitochondria

Oxa1l Apool Acsl4 Acadl Ndufs2 Slc25a17 Mosc2 Uqcrfs1 Ugt1a6a Dap3 Atp5d Ckmt1 Bcs1l Atp5c1 Immp2l Timm44 Hadh Slc25a4 Uqcrc2 Mdh2 Pmpcb Atp5a1 Got2 Vdac2 Atp5f1 Tufm Ndufb5 Phb2 Slc25a5 Pnpt1 Slc25a3 Msto1 Mrpl19 Mrpl16 Atp5b Aifm1 Bckdhb C1qbp Hspd1 Atad3a

d.

n ion  Abu lat A s N n mR Tra Nucleus

Lysosome Npc2 Ap4m1 Lamp2 Clta Gba Ctsh Galns Ctsz Napsa Atp6v1h Ctss Ctsd Ctsc

Proteasome Psmb8 Psmb1 Psmf1 Psmd4 Psme1 Psma5 Psmb3

­3

­1

1

3

PI Signaling

Actin  Cytoskeleton

Eif2s1 0610007P08Rik Senp5 Setd8 Exo1 Zzz3 Depdc1a Triobp E2f6 Zcchc17 Rngtt Smek2 Rfwd3 Ppp1cb Abl1 Cbfb Rnf34 Cux1 Chek2 Rnf14 Mapkap1 Atf2 Fancd2 Son Cuedc2 Qk Chfr Lef1 Atrx Sfmbt1 Elf2 Mef2a Stk4 Mdm1 Mll5 Rcor1 Pou2f1 Maf1 Usp11 Clk4 Ncaph2 Clk1 Ssbp2 Bach2 Zfp238 Pde4b Afmid Lats2 Zeb2 Irf1 Ppp3ca Sesn3 Foxn3 Tcf12 Bcl6 Itpkb Pik3ca Dgk! Calm1 Ppp1cb Wasf2 Pik3ca Iqgap1 Cyfip2