TUNISIA

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017

Welcome to TUNISIA Tunisia is one of the most modernised countries of Africa and has one of the strongest economies. With green forests to the north, lovely beaches along the coast and the Sahara in the south. This hospitable land of colours and contrasts; spices and scents, invites the visitor to enjoy its natural beauty, ancient cities and the friendliness of its people. Welcoming guests to its shores has long been an honoured Tunisia tradition and an impressive infrastructure of modern hotels restaurants, and international airports has been developed to enhance the comfort and pleasure of millions of travellers to this exotic destination.

Geography Climate: Northern Tunisia has a typical Mediterranean climate, with hot summers and mild winters. The mountains in the North West occasionally see snow, while the south tends toward warmer and drier weather.

(April 4, 2017)

Tunis 163,610 square miles 12.000 millions Tunisia’s currency is the Tunisian Dinar (TND) 1 US Dollar = 2.2829 TND 1 Euro = 2.41957 TND

Language:

Arabic, French, English, Italian and German

Capital: Area: Population: Currency: Exchange Rate:

Sfax is a city in Tunisia, located 270 km southeast of Tunis. The city, founded in AD 849 on the ruins of Taparura and Thaenae, is the capital of the Sfax Governorate (about 955,421 inhabitants in 2014), and a Mediterranean port. Sfax has a population of 330,440 (census 2014). The main economic activities of Sfax are industries (phosphate processing), agriculture (olive and olive oil, nuts), fishing (largest fishing port in Tunisia) and trade (import-export). The city is often described as Tunisia's "second city" (after the capital Tunis).

Hédi Chaker Street in Sfax

Looking across the Place de la République towards Sfax city hall

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Sfax – Thyna International Airport


Welcome to the 3rd ESBM Conference Applications of mathematics, physics, chemistry and computer science to problems raised by modern biology and medicine have become intensive research topics in the recent past decade. With the recent development of multidisciplinary domains such as nanotechnology biostatistics, bioinformatics, and systems biology, many leading scientists working in different scientific fields have been attracted by applications of their work to Biology and Medicine. Building on the success of the two past editions of ESBM in 2013 and 2015, respectively under the principal topics of computational biology and genomics and Nanotechnology, the third edition will be organized on the strategic topics of Big Data in biology and medicine and E-health with wide cooperation and strong support of active academic and professional partners in the field . A final session will be dedicated to Biometry and forensics, a major concern in the security of nations in their battle against terrorism. The third edition of the International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017), will be organized by the Tunisian Association of Academic Researchers ATCU, in collaboration with Technopark of Sfax and the Digital Research Centre of Sfax from 4th to 7th May 2017 in Sfax, Tunisia. The third edition of the ESBM Conference will include the presentation of 40 long papers, 28 posters talks and 6 keynote lectures in different fields of the ESBM Conference. The partners of the third ESBM Conference are: FSS, ISIMS, ENETCOM, FSEGS, ISGI, CBS, University of Sfax and IFT. In addition, the conference is sponsored by: Technopark Sfax, Sakiet Ezzit Municipality, Laboratoires SIVO, SOTECA, Htds, Steros, Getwireless, Computer System, CleanExpert and Banque de l‘Habitat. The main topics of the third ESBM Conference are -

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Health Data & Models – Healthcare Data Architecture and Terminology Standards – Clinical Data Visualisation Standards – Electronic medical records (EMR) and electronic prescription – Federated Electronic Health Records – Healthcare Information systems – Data quality assessment and improvement – Interoperability issues – Evolutionary and longitudinal patient and disease models Health Data Processing – Data preprocessing, cleansing, management and mining – Computer-aided detection, hypothesis generation and diagnosis – Big data analysis, prediction and prevention – Smart health and Mobile computing – Medical Image/video processing and computer vision – Cognitive algorithms for healthcare handling dynamic context management – Augmented reality, Motion detection and activity recognition – Security, confidentiality & privacy issues 2

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 -

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Devices, Infrastructure & Communication – Wearable & connected devices – In/on/around-body sensors and actuators – Biosensors at the micro/nano-scale – RFID and localization techniques – Computing/storage infrastructures for e-Health – Communication infrastructures, architectures and protocols for e-Health – Body area networking and cloud-integrated networking – Cognitive communication for medical bands – IoT devices & architectures for Smart Healthcare E-Health Services & Applications – E-Health services/applications for chromic & serious diseases – E-Health services/applications for elderly people – E-Health services/applications for public health – E-Health services/applications for rural areas – Security, privacy and trust for e-Health services/applications Nanobiotechnology & Nanomedicine – Medical physics, Medical Imaging, Radiation Therapy, Dosimetry,Biomedical signal and Image processing – Nanomaterials, Nanotoxicity, DNA nanotechnology, Nanotechnology in Drug Discovery and Development, – Novel Drug Delivery Systems – Biosensors – Forensic sciences – Biomechanics – Microfluidics Systems Biology & Forensics – Computational Systems biology – Designing and modeling of biological systems – Statistical methods for biological and genomics data analysis – Individual identification based on DNA technologies – Genomics populations diversity

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COMMITTEES General Chair Rafik Bouaziz, University of Sfax, Tunisia

PC Chairs Mohamed Jmaiel, CRN Sfax, Tunisia Ramzi Maalej, FS Sfax, Tunisia Ahmed Rebai, CB Sfax, Tunisia

Industrial Chair Nejib Abida, Technopark Sfax, Tunisia

Organizing Committee Chairs Slim Kallel, FSEG Sfax, Tunisia Ismael Bouassida Rodriguez, ISIM Sfax, Tunisia

Organizing Committee Noomen Hachicha, CRN Sfax, Tunisia Imen Ben Rebeh, University of Gabes, Tunisia Hela Gargouri, CB Sfax, Tunisia Rania Abdelhedi, CB Sfax, Tunisia Hichem Azzouz, CB Sfax, Tunisia Rihab Kallel, CB Sfax, Tunisia Ghazi Mhiri, Technopark Sfax, Tunisia Mouna Torjmen, University of Sfax, Tunisia Afef Jmal Maâlej, ReDCAD, ENIS, Tunisia Nesrine Khabou, ReDCAD, ENIS, Tunisia

Program Committee Chokri Abdelamoula, University of Sfax, Tunisia Salih Abdelaziz, University of Montpellier, France Adnane Abdelghani,University of Carthage, Tunisia Slim Abdelkafi, University of Sfax, Tunisia Adnane Abdelghani,University of Carthage, Tunisia Hamdi Aloulou, University of Montpellier, France Zouheir Baccar, INRAP, Tunisia Kamel Barkaoui, CNAM Paris, France Mounir Ben Ayed, University of Sfax, Tunisia Chokri Ben Amar, University of Sfax, Tunisia Ahmed Ben Hmida, University of Sfax, Tunisia Alia BenKahla, Institut Pasteur of Tunis, Tunisia Hafedh Ben Oueda, Univesity of Monastir, Tunisia Mondher Besbes, Institut d’Optique Graduate School, France 4

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 Mounir Besbes, CHU Saleh Azaiz, Tunisia Hatem Besbes, University of Tunis ElManar, Tunisia Rafik Bouaziz, University of Sfax, Tunisia François Boucher, Joseph-Fourier University of Grenoble, France Anas Bouguecha bouguecha, University of Hannouver Michael Canva, University of Sherbrooke, Canada Angel Carracedo, University of Santiago de Compostella, Spain Lamia Chaari, University of Sfax, Tunisia Lotfi Chaari, University of Sfax, Tunisia Wissem Cheikhrouhou, Digital Research Center, Tunisia Ahmed Chemori, University of Montpellier, France Abdallah Chehaidar, University of Sfax, Tunisia Philippe Cinquin, Joseph-Fourier University of Grenoble, France Marcos Da Silveira, Institute of Science and Technology, Luxembourg Michel Dojat, Joseph-Fourier University of Grenoble, France Jamel Daoud, University of Sfax, Tunisia Amel Daoud, CHU, Sfax, Tunisia Habib Elhouichet, University of ElManar, Tunisia Mourad Elloumi, University of Tunis ElManar, Tunisia Ahmed Fakhfakh, University of Sfax, Tunisia Mohamed Ali Feki, Nokia, Belgium Amel Gaied, University of Tunis ElManar, Tunisia Faiez Gargouri, University of Sfax, Tunisia M’hamed Grati, University of Miami Miller School of Medicine, USA Pietro Gucciardi, University of Messina, Italy Hassen Hadj Kacem, university of Sharjah, UAE Sumi Helal, University of Florida, USA Nejmeddine Hentati University of Sfax, Tunisia Andreas Herrmann, Friedrich Schiller University Jena, Germany Nawel Jmail, University of Sfax, Tunisia Arwa Kamoun, CHU Habib Bourguiba Sfax, Tunisia Mohamed Ksibi, University of Sfax, Tunisia Dhafer Laouini, Pasteur Institute of Tunis, Tunisia Elyes Lamine Mines-Albi Camaux, France Nabil Maalej, King Fahd University of Petroleum and Minerals, KSA Halima Mahjoubi, University of ElManar, Tunisia Afif Masmoudi, University of Sfax, Tunisia Sabeur Masmoudi, Centre of Biotechnology of Sfax, Tunisia Mouna Marrakchi-Sellami, University of Tunis ElManar, Tunisia Hassene Mnif, University of Sfax, Tunisia Mounir Mokhtari Mmines Telecom, France Mohamed Mosbah, LaBRI Bordeaux, France Fabrice Navarro, CEA- LETI, France Gregory Nuel, Pierre and Marie Curie University, France Abdul Kareem Parchur, Medical College of Wisconsin, USA Philippe Sabatier, University of Grenoble Alpes Haitham Sghaier, National Center for Nuclear Sciences and Technologies, Tunisia Bheeshma Pratap Singh, Banaras Hindu University, India Ismael Bouassida Rodriguez, University of Sfax, Tunisia Joel Rodriguez, BlueCore, New York, USA 5

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 Christian Russel, Otto Schott Institute, Germany Alessandra Toncelli, University of Pisa, Italy Nalluri Veeraiah, Acharya Nagarjuna University, India Houda Yacoub, Institut Pasteur of Tunis, Tunisia Rami Yared, University of Sherbrooke, Canada El Sayed Yousef, King Khalid University, KSA Habib Zaidi, Geneva University Hospital, Switzerland Najla Kharrat, Centre of Biotechnology of Sfax, Tunisia Imen Ayadi, University of Sfax, Tunisia Abdellatif Maalej, University of Sfax, Tunisia

Additional Reviewers Gayatri Sharma Jaidip Jagtap Bassem Bouaziz Mahmoud Ghorbel Monia Ben Brahim Soumaya Marzouk Afef Mdhaffar

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Friday 5 May 2017

Saturday 6 May 2017

Sunday 7 May 2017

Keynote Lecture (SUMI HELAL)

Keynote Lecture (MATTHEW

09h00 - 10h30 BLASCHKO)

Welcome (Registration) + Opening A Perspective on Establishing Research and Educational Activities in Digital Health, Successful Aging and other Quality-of-Life Areas

10h30 - 11h00 11h00 - 12h30

Coffee Break

Keynote Lecture (PHILIPPE CINQUIN) Innovation in Implantable Medical Devices: towards symbiotic robots?

12h30 - 14h00 14h00 - 15h30

Biology Session 1 : Computational Biology

Lunch

E-Health Session 4: Medical Image Processing

Coffee Break

E- Health Session 2: Medical Information and Data

Coffee Break

Round Table (Strategic E-Health Session 3: IoT for Nanotechnology Session 2: Development of Health and Health Technology for Health Sectors) Nanomedicine & Closure

Lunch

E-Health Session 1: Signal Processing

15h30 - 16h00 16h00 - 17h30

Coffee Break

Deep learning in medical image analysis: Opportunities and constraints

Lunch

Biology Session 2 : NGS Technologies and Data Analyses

Coffee Break

Nanotechnology Session 1: Nanotechnology Session 3: Biology Session 3: Nano Bio-Sensors Nanomaterials and Forensics Biotechnology/Forensics

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ESBM’2017 Program Friday 5 May 2017 09h00 - 10h30

Welcome (Registration) + Opening

10h30 - 11h00

Coffee Break

11h00 - 12h30

Keynote Lecture Session Chair: RAFIK BOUAZIZ, University of Sfax, Tunisia « Innovation in Implantable Medical Devices: towards symbiotic robots? » PHILIPPE CINQUIN

12h30 - 14h00 14h00 - 15h30

Lunch E-Health Session 1: Signal Processing Session Chair: LOTFI CHAARI, University of Sfax, Tunisia EEG Feature's Optimization for Epilepsy Diagnosis Badreddine MANDHOUJ, Mohamed Ali CHERNI, Ines BEN ABDELAZIZ, Mounir SAYADI and Farhat FNAIECH CEP4CVD: CEP for Cardiovascular Disease Khalil CHARFI, Afef MDHAFFAR, Ismael BOUASSIDA RODRIGUEZ, Leila ABID, Mohamed JMAIEL and Bernd FREISLEBEN 3D Brain Activity Localization Using Smooth WMN-FOCUSS Method Wassim ZOUCH and Ahmed BEN HAMIDA Towards Medical Image Re-ranking based on Convolutional Neural Networks Nada SOUISSI, Hajer AYADI and Mouna TORJMEN Biology Session 1 : Computational Biology Session Chair: AHMED REBAI, CB Sfax, Tunisia Screening of genetic variations in genomic sequences encoding charged regions in human proteins Sabrine BELMABROUK, Najla KHARRAT, Rania ABDELHEDI, Amine BEN AYED, Riadh BENMARZOUG and Ahmed REBAI Tcl/tk-based Interface for accessing and modelling of high-throughput Cancer Data Karim MEZHOUD A data Fusion approach based on Dempster-Shafer theory for the Prediction of Auxins response elements Nesrine SGHAIER, Belgcem Chibani RHAIMI and Ahmed REBAI 8

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 In silico analysis for predicting the pathogenicity of mitochondrial DNA mutations in patients with neuromuscular cytopathies phenotypes Emna MKAOUAR-REBAI, Rahma FELHI, Lamia BEN MANSOUR, Mouna TABEBI, Olfa FERSIALILA, Imen CHAMKHA, Marwa MAALEJ, Marwa AMMAR, Fatma KAMMOUN, Leila KESKES, Mongia HACHICHA and Faiza FAKHFAKH 15h30 - 16h00

Coffee Break

16h00 -17h30

E-Health Session 2: Medical Information and Data Session Chair: RIDHA FRIKHA, VetAgro Sup. de Lyon A Secure And Lightweight IoT Based 12-Lead ECG Signal Acquisition System Manish KUMAR, Sunil KUMAR, Rajat BUDHIRAJA, M.K DAS, Amitabh SINGH BAFILA and Sanjeev SINGH A Robust Cryptographic Model For Securing Medical Information Sunil KUMAR, Manish KUMAR, Rajat BUDHIRAJA, M.K DAS and Sanjeev SINGH Assistance in the drafting of an epidemiological research protocol Mayara KHADHRAOUI, Hatem BELLAAJ, Jihene MAATOUG and Mohamed JMAIEL Cognitive Computing for disease registry form validation: Application to tunisian Diabetes type-1 registry Maryam HAMMAMI, Hatem BELLAAJ and Mohamed JMAIEL Nanotechnology Session 1: Nano Bio-Sensors Session Chair: Ramzi Maalej, FS Sfax, Tunisia

Keynote Lecture « Detection and functional characterization of biomolecules by Plasmon-Enhanced Raman Spectroscopy » PIETRO GUCCIARDI Nano-biotechnologies and biosensors for medical applications Mouna MARRAKCHI, Xiaobo LIU and Silvana ANDREESCU Hydrocalumite Nanofilms for Polyphenol Biosensor ‎elaboration Asma SOUSSOU, Ibtissem GAMMOUDI, Adel KALBOUSSI, Christine GRAUBY-HEYWANG, Touria COHEN-BOUHACINA and Zouhair M. BACCAR Development of immunosensors for endocrine disrupting (EDCs) detection and quantification Najet BELKHMASSA, Teresa ROCHA SONTOS and Mohamed KSIBI Optimized Nanostructured Transducers for SERS Detection Sameh KESSENTINI and Dominique BARCHIESI 9


Saturday 6 May 2017 Keynote Lecture Session Chair: PHILIPPE SABATIER, University of Grenoble Alpes 09h00 - 10h30 « A Perspective on Establishing Research and Educational Activities in Digital Health, Successful Aging and other Quality-of-Life Areas » SUMI HELAL 10h30 - 11h00

Coffee Break

11h00 - 12h30

E-Health Session 3: IoT for Health Session Chair: MOUNA TORJMEN, University of Sfax, Tunisia A Comparative Study between Regression-based Models for Medical time series Forecasting Lamia BEN AMOR and Imene LAHYANI My Sight : a new design of wearable navigation support system for the visually impaired and blind people Yassine BOUTERAA Semantic Reasoning for an AAL Platform Hamdi ALOULOU, Thibaut TIBERGHIEN, Mounir MOKHTARI and Romain ENDELIN Out of Body simulation using camera and HMD system Kais SIALA, Mohamed KHARRAT and Mohamed ABID Nanotechnology Session 2 : Nanomedicine Session Chair: Pietro Giuseppe Gucciardi, IPCF-CNR, Italy Keynote Lecture « Nanotechnology and New ideas of Start-Up in Developing Countries » ADNANE ABDELGHANI Lanthanide Nanoparticles for MRI and Fluorescence Imaging Nabil MAALEJ, Ahsanulhaq QURASHI, Ramzi MAALEJ, Raouia LACHHEB, Achraf Amir ASSADI, M. Nasiruzzaman SHAIKH and Mohammad A. GONDAL Characterization and development of an immunosensor for C - reactive protein (CRP) detection Imen HAFAID Electrochemical impedance spectroscopy on interdigitated gold microelectrodes for glycosylated Human Serum Albumin characterization Nadra BOHLI, Hanen CHAMMEM, Olivier MEILHAC, Laurence MORA and Adnane ABDELGHANI Design and Simulation of Magnetic Microchannel Toward Cancer Cell Separation from Blood Omer SAEED, Emran SUHERYANI and Deng YULIN

12h30 - 14h00

Lunch 10

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 14h00 - 15h30

E-Health Session 4: Medical Image Processing Session Chair: HAMDI ALOULOU, University of Montpellier, France Gamma correction based algorithm for non-contrast CT scan enhancement Fathi KALLEL, Ahmed BEN HAMIDA and Khalil CHTOUROU A Decision support system of high computing architectures for complex medical imaging algorithms Mariem MEKKI, Lotfi CHAARI, Nebras GHARBI and Itebeddine GHORBEL Towards an advanced Methodology for Attenuation Correction in PET-MR Modalities: Application to Whole Body Imaging Mouna SAHNOUN and Ahmed BEN HAMIDA Contribution to the development of a new system to help diagnose cognitive diseases Zouhour MAÂTAR, Chokri ABDELMOULA and Mohamed MASMOUDI Biology Session 2: NGS Technologies and Data Analyses Session Chair: SABER MASMOUDI, CB Sfax, Tunisia ABI Base Recall: Automatic correction and ends trimming of DNA sequences Zakaria ELYAZGHI, Loubna EL YAZOULI, Khalid SADKI and Fouzia RADOUANI Whole exome sequencing in a UAE family affected with deafness and carrying the p.Cys169Tyr variant Abdelaziz TLILI Exome sequencing of Tunisian family affected with congenital hypogonadotropic hypogonadism Mariam MOALLA, Faten HADJ KACEM, Abdullah MUTAIRI, Mohamed ABID, Mouna MNIFFEKI and Hassen HADJ KACEM Targeted High-throughput Sequencing for the identification of pathogenic variants responsible for hereditary diseases in Tunisian families Amal SOUISSI, Imen CHAKCHOUK, Mariem BEN SAID and Saber MASMOUDI

15h30 - 16h00 16h00 - 17h30

Coffee Break Nanotechnology Session 3: Nanomaterials and Forensics Session Chair: Adnane Abdelghani, University of Carthage, Tunisia Keynote Lecture « Nanoparticles for Fingermark Detection: A Look Through the Looking-Glass » ANDY BÉCUE Size and shape determination in NEMS mass sensors Adam BOUCHAALA Enhanced Copy Number Variants Detection from High Throughput Targeted DNA Sequencing Amal BOUZID, Imen CHAKCHOUK, Tim DE MEYER and Saber MASMOUDI 11

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 16h00 - 17h30

Influence of hip prosthesis size and its coating area on ‎bone remodelling Amer ALMOHALLAMI, Matthias LERCH, Henning WINDHAGEN, Bernd-Arno BEHRENS and Anas BOUGUECHA Suspension Stability of TiO2 nanopowders doped and co-doped by Er and Yb and prepared by sol-gel process Ikram BENAMMAR, Rached SALHI, Ramzi MAÂLEJ and Jean Luc DESCHANVRES Time-frequency analysis from impedance cardiography signal Asma AYADI, Wassila SAHTOUT and Ridha BENSALAH Biology Session 3: Biotechnology/Forensics Session Chair: Balkiss Bouhaouala-Zahar, Institut Pasteur de Tunis Design of a biosensing platform using anti-chrysophsin polyclonal for fish health immunotracing Wael BELLILA, Abdelmoneim MARS, Sonia FEKIH, Ammar MAROUANI, Monia EL BOUR, Noureddine RAOUAFI, Andrea SANTULLI and Balkiss BOUHAOUALA-ZAHAR Second Generation Sequencing and SNP Analysis in Forensic Genetics Faten RMIDA, Imen CHAKCHOUK, Arwa KAMMOUN, Wiem BEN AMAR, Nadia MAHFOUDH, Samir MAATOUG and Saber MASMOUDI Screening of selected biomarkers related to mitochondrial dysfunction and associated with the severity of autism measured by Childhood Autism Rating Scale (CARS) Madina Asma KHEMAKHEM, Afaf EL-ANSARY, Laila AL.AYADHI and Abir BENBACHA ALGHANNOUCHI

Sunday 7 May 2017

09h00 - 10h30

Keynote Lecture Session Chair: MOHAMED JMAIEL, CRN Sfax, Tunisia « Deep learning in medical image analysis: Opportunities and constraints » MATTHEW BLASCHKO

10h30 - 11h00

Coffee Break

11h00 - 12h30

Round Table « Strategic Development of Health and Technology for Health Sectors » & Closure

12h30 - 14h00

Lunch

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Invited Speakers Innovation in Implantable Medical Devices: towards symbiotic robots? May 5

11h00 - 12h30 By Philippe Cinquin, University Joseph Fourier, France

Instructor Biography: Philippe Cinquin, 60, is Professor of Medical Informatics at Grenoble (France). He heads TIMC-IMAG, UMR5525, a Research Unit of CNRS and of Univ. Grenoble Alpes, and co-heads CIC-IT 1406 (Centre of Clinical Investigation – Technological Innovation) of INSERM and Grenoble’s University Hospital. He holds a PhD in Applied Mathematics and is a Medical Doctor. In 1984, he launched a research team on Computer-Assisted Medical Interventions (CAMI), which led to innovative surgical practice, benefiting to more than 100 000 patients, thanks to the creation of several startup companies. He recently turned on intra-body energy scavenging in order to power implanted medical devices. Dr. Cinquin was the recipient of the 1999 Maurice E. Muller Award for excellence in computer-assisted orthopedic surgery, of the 2003 CNRS Silver Award, of the 2013 CNRS Innovation Award, and of the 2014 Ambroise Paré Award of the French Academy of Surgery. He was finalist for the 2014 European Inventor Award for a Glucose BioFuel Cell capable to power implanted medical devices. Lecture Abstract: Implantable Medical Devices extend surgeon’s action, allowing compensation of failing vital functions. They implement the classical robotic loop: “Perception – Decision – Action”. We will illustrate the interest of this loop in CAMI (Computer Assisted Medical Interventions). This is the ground on which surgical navigation systems or surgical robots were designed, leading to the creation of more than 10 startup companies that commercialized devices used on hundreds of thousands of patients. The specificities of innovation in medical devices will be discussed on instances from this domain. We will then see how this experience led to the design of implantable robots, which are autonomous not only to take decisions, but also to scavenge their energy from the glucose that is naturally present in the physiological fluids. We will conclude on the possible emergence of a new family of Implantable Medical Devices, symbiotic robots.

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Detection and functional characterization of biomolecules by Plasmon-Enhanced Raman Spectroscopy May 5

16h00 - 17h30 (Nanotechnology Session 1) By Pietro Giuseppe Gucciardi, IPCF-CNR, Italy

Instructor Biography: Pietro Giuseppe Gucciardi is a senior researcher and coordinator of the Spectroscopy, Imaging and Trapping Group at the Institute for the Chemical and Physical Processes, National Research Council (IPCF-CNR), Messina, Italy. His main research interests are in the field of near-field optics and plasmon-enhanced spectroscopies (SERS/TERS). His research includes the combination of optical tweezers with Raman/SERS spectroscopy for the analysis of individual nanostructures and the development of advanced nanobiosensors. Lecture Abstract: Surface- Enhanced Raman Scattering (SERS) and Tip-Enhanced Raman Scattering (TERS) exploit the enhancement of the local electromagnetic field induced by optical nanoantennas and nano-tips to largely amplify the Raman scattering of molecules located in the near-field of these structures, the so called hotspots. With SERS or TERS, Raman scattering amplifications up to 108- 1010 can be obtained. In this talk we will overview the most recent advancements in the field of plasmon enhanced Raman spectroscopies for the detection of biomolecules and characterization of their functional activity. This will include of novel large area SERS-active substrates, the SERS detection of proteins in liquid by means of Raman tweezers setups and the Tip-Enhanced Raman analysis of biomolecules.

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A Perspective on Establishing Research and Educational Activities in Digital Health, Successful Aging and other Quality-of-Life Areas May 6

09h00 - 10h30 By Sumi Helal, University of Florida, USA

Instructor Biography: Abdelsalam (Sumi) Helal is a senior Professor in the Computer & Information Science and Engineering Department at the University of Florida, and Director of the Mobile and Pervasive Computing Laboratory. He is co-founder and Director of the Gator Tech Smart House, a real-world deployment project that aims to identify key barriers and corresponding technological solutions to make the Smart Home concept a common place (creating the “Smart Home in a Box” concept). He has recently been awarded a Finland Distinguished Professorship - FiDiPro (2011-2014). His active areas of research focus on pervasive and ubiquitous systems and their human-centric applications. Specifically he and his research team investigate middleware, programming models, and architectural issues to define and support the entire lifecycle of smart spaces including city-scale deployments. More recently, he and his students have been exploring architectural and ecosystem issues surrounding the emerging IoT. Specifically, he is pursuing novel programming models and ecosystem enablers for the IoT. From 2001-2007, Professor Helal served as Director of Technology Development of the University of Florida Rehabilitation Engineering Research Center (RERC) on Aging and Independence. He is co-founder of the IEEE Pervasive Computing magazine and has served on its editorial board since 2002. He currently serves as the Editor-in-Chief of IEEE Computer, the Computer Society’s flagship and premier publication. He founded or co-founded three startups: Phoneomena, Inc. (2002-2007, mobile middleware company), Pervasa, Inc., (2006-2011, sensor and device integration middleware company) and Spaceify Oy (2015, smart space middleware company). He is inventor or co-inventor on 9 published US patents. Professor Helal is a Fellow of the IEEE. Lecture Abstract: Recent advances in mobile and wearable technology as well as the Internet of Things (IoT) provide a glimpse into our future and reveal exciting visions of many “smarts”: smart homes, smart cities, workplaces, hotels, schools, hospitals, clinics, and much more. Driven by a technological revolution offering extremely low-power, wirelessly connected IoT, we can now envision and prototype impressive systems and applications to improve health, wellbeing, and quality of life, and to assist the elderly and the disabled. But as we begin to understand many of the complex interplays between technology, users, realworld applications, and theory, we are better positioned today to move beyond envisioning and prototyping, to advance critical ecosystem enablers that will realize a thriving industry of digital health products, infrastructures and services. Such an ecosystem is necessary for the anticipated disruptive transformations in healthcare and eldercare. Learning, understanding, and validating ecosystem elements through real-world deployments and multidisciplinary applications have been the hallmarks of my research approach. Over the past 15 years, I have focused on mobile and pervasive computing systems and their applications in smart health, aging, and disabilities. In this keynote, I will share my experiences (good and bad) in establishing and growing a program on digital health, successful aging and other quality-of-life areas especially as they relate to disabilities and the associated deficit in independence and societal inclusiveness. 15


Nanotechnology and New ideas of Start-Up in Developing Countries May 6

11h00 - 12h30 (Nanotechnology Session 2) By Adnane Abdelghani, University of Carthage, Tunisia

Instructor Biography: Prof.Dr.A.Abdelghani is a Full Professor at the National Institute of Applied Science and Technology (INSAT, Tunisia) working mainly in the field of Microsensors and Microsystems. He obtained the Habilitation in Physics in Tunisia (faculty of Science of Tunis) in 2004 and a Habilitation (worlwide recognition for conducting and leading research) in "Sciences pour l’Ingénieur" in 2009 at the Ecole Normale Supérieur de Cachan (France). He is now the leader and principal investigator of a research group working mainly on gas sensors based on functionalized carbon nanotubes (metallic oxides, nanowires, nanoneedles, polymers) and on the development of interdigitated gold microelectrodes integrated in microfluidic cell for bacteria analysis in biologic medium. He published more than 90 papers in International Journals (H-index 24, December 2016) and supervised more than 12 Ph.D theses and 30 master’s student. He is deeply involved in industrial applications in his field of research with implications for the design and the development of affordable and cost-effective sensing devices for diagnostics and theranostics which will have an effective impact in the developing countries. He received the Tunisian President Award of the “best scientific researcher” in Tunisia in 22 July 2015. Lecture Abstract: We present an approach for the use of devices for analyte (pesticides, bacteria, heavy ions, C-Reactive Protein, neurotoxin gaz,v apors, etc..) detection for different applications (food analysis, water analysis, medical diagnostic, security, environment, etc..). Most of the analyze detection systems used are time consuming, enable remote sensing and need different steps of preparation. The development of new devices needs laboratory experiment for stability, rapidity and reproducibility studies. We will show the need of the market and the applications for such devices in biotechnology, medicine and security and namely for developing countries.

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Nanoparticles for Fingermark Detection: A Look Through the Looking-Glass May 6

16h00 - 17h30 (Nanotechnology Session 3) By Andy Bécue, University of Lausanne, Switzerland

Instructor Biography: Andy Bécue obtained his licence in chemistry in 2000 and his PhD in 2004 from the University of Namur (Belgium). In 2004, he did his post-doc at the École des Sciences Criminelles – University of Lausanne (Switzerland), funded by the Swiss National Fund (SNF #200021-105580). He was a lecturer from 2005 to 2009, was an Ambizione fellow from 2009 to 2013 (SNF #PZ00P2_121907 and PZ00P2_139952), and is currently a tenuretrack assistant professor at the ESC/UNIL. His research interests are focused on the detection of traces/marks of forensic interest (e.g., fingermarks, body fluids) to improve the detection capability of investigators in the field.

Lecture Abstract: Fingermark detection is one of the most important research fields in forensic science, mostly due to the critical role played by fingerprints in criminal investigations. More particularly, the development of new and efficient detection techniques remains a matter of primary interest for forensic practitioners/scientists and for a range of skilled scientists (e.g., chemistry, biology, material science). This interdisciplinary interest for the field recently led to an increasing number of publications referring to high-end technological means to detect fingermarks, among which the use of functionalized nanoparticles. Still considered as an emerging field from a forensic point of view, nanoparticles nevertheless currently represent a prevailing research topic in terms of publications linked to fingermarks. The aim of this talk is to propose a critical overview of the use of nanoparticles to detect fingermarks, especially because technological promises are not always tuned with forensic needs. This talk aims at providing a reasoned review to help sharing a common view and conducting efficient joint research.

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Deep learning in medical image analysis: Opportunities and constraints May 7

09h00 - 10h30 By Matthew Blaschko, KU Leuven, Belgium

Instructor Biography: Matthew B. Blaschko received the B.S. degree from Columbia University and the M.S. degree from the University of Massachusetts Amherst. He also received the Doctorate in electrical engineering and computer science (summa cum laude) from the Technische Universität Berlin for work done at the Max Planck Institute for Biological Cybernetics, Tübingen, Germany. Subsequently, he was a Newton International Fellow in the Department of Engineering Science, University of Oxford and received the Habilitation from the Ecole Normale Supérieure de Cachan, France. Prior to joining KU Leuven, he was a Permanent Research Scientist in the INRIA Saclay Research Center and a Faculty Member at Ecole Centrale Paris. From 2015 he is a Professor in the department of Electrical Engineering at KU Leuven, Belgium. His research interests include machine learning techniques applied to visual data. Prof. Blaschko has been guest editor of a special issue in the International Journal of Computer Vision and an area chair for top venues in computer vision and machine learning including Neural Information Processing Systems (NIPS), Artificial Intelligence and Statistics (AISTATS), and the British Machine Vision Conference (BMVC). He received the Main Prize of the German Association for Pattern Recognition and Best Paper Awards at the IEEE Conference on Computer Vision and Pattern Recognition (CVPR) and European Conference on Computer Vision (ECCV). Lecture Abstract: Deep learning has had an immense impact on computer vision and image analysis in a wide range of domains. The greatest successes have come from domains in which large amounts of training data are readily available, such as photographs collected through social media and image sharing websites. The advantages of deep learning are less apparent when the amount of training data are small, such as is inherently the case with medical data due to (i) rare diseases, (ii) the high expense of medical image acquisition, and (iii) regulatory restrictions in compiling data from multiple sites and jurisdictions. In this talk, I will demonstrate several successful applications of deep learning in the medical domain, and highlight strategies and mathematical advances that help to extend the benefits of deep learning within the fundamental constraints of our problem domain.

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List of Posters Application of Z-curve parameters for the prediction of Auxin Responsive Elements Nesrine SGHAIER and Ahmed REBAI Efficient temperature sensing using photoluminescence of Er/Yb implanted thin films Nour HAMZA, Ramzi MAALEJ, Edwardo ALVES and Abdul Kareem PARCHUR Luminescent studies of Dy3+ ion in alkaline earth Aluminosilicate glasses Mohamed ZEKRI, Rim TURKI, Ramzi MAALEJ, Christian RÜSSEL, Andreas HERRMANN and Kamel DAMAK Bioinformatics analysis of human chemokine receptors Karim ALEM and Ahmed REBAI Using citation mapping to automate the choice of references for the creation of a biomedical systematic review Houcemeddine TURKI Spectroscopic analysis of trivalent Nd3+/Yb3+ ions codoped in PZS host glasses as a new laser material at 1.06µm Afef BEGUITH Optical and luminescent properties of trivalent Samaruim doped Aluminosilicate Glasses Rim TURKI, Mohamed ZEKRI, Kamel DAMAK, Ramzi MAALEJ, Andreas HERRMANN and Christian RÜSSEL A Novel Preprocessing Approach for Nystagmus Analysis Amine BEN SLAMA, Aymen MOUELHI, Sondes MANOUBI, Hedi TRABELSI, Sofien BEN RHOUMA and Mounir SAYADI Judd Ofelt analysis and experimental spectroscopic study of erbium doped phosphate glasses Raouia LACHHEB, Andreas HERRMANN, Kamel DAMAK, Christian RÜSSEL and Ramzi MAALEJ Rapid And Sensitive Strategy To Control Aggregate Forms Of rhG-CSF Induced By Thermal Stress Using Agilent 2100 Bioanalyzer Hazar KRAIEM, Balkiss BOUHAOUALA-ZAHAR and Luc FILLAUDEAU Nanomedecine: a challenge for acute lymphoblastic leukemia therapy Rim FRIKHA, Neila BELGUITH and Hassen KAMOUN Comprehensive analysis of MTHFR polymorphism for personalized therapy in leukemia Rim FRIKHA, Nouha BOUAYED and Tarek REBAI Diseases of the Wnt Signaling Pathway: About a Tunisian family with Gardner syndrome and a rare germline APC deletion Nouha BOUAYED ABDELMOULA, Rim LOUATI, Mustapha BENAZIZA, Yoldez KAABI, Fatma TURKI, Wafa ALOULOU, Naourez MOALLA GOUIA and Samir ALOULOU Severe familial adenomatous polyposis associated to a rare non sens mutation of exon 13 of the β-catenin WNT signaling pathway regulator: APC Nouha BOUAYED ABDELMOULA, Rim LOUATI, Samir ALOULOU, Fatma TURKI, Yoldez KAABI, Wafa ALOULOU and Naourez MOALLA GOUIA 19

The Third International Conference of Engineering Sciences for Biology and Medicine (ESBM 2017) Sfax, Tunisia, May 04 – 07 2017 Participatory approach for ecologically sustainable sanitation Khaoula LAMZOURI, Mustapha MAHI, El Houssine BARTALI, Tsugiyuki MASUNAGA, Laila MANDI and Said OUATTAR Photoluminescence properties of CdSrP2O7:Eu2+ blue phosphor for white LED applications Mouna DERBEL, Aïcha MBAREK, Geneviève CHADEYRON and Mohieddine FOURATI Investigation of GSTM1 and GSTT1 genotypes effect on mitochondrial disease among a Tunisian population Raouia GHORBEL, Ghada BEN SALAH, Leila AMMAR-KESKES and Faiza FAKHFAKH Practical application of the scientific study of energy saving technically in Gaza Governorate electrical grid and its relationship with the local community, public sector and economically Husam AWWAD Enhancement of Cerium doped aluminosillicate glasses emission for X-ray imaging Assadi Achraf AMIR, Kamel DAMAK, Andreas HERRMANN, Christian RUSSEL and Ramzi MAALEJ Unsupervised image segmentation using THMRF model Mourad ZRIBI, Mouna ZITOUNI and Afif MASMOUDI Web Services in Service of e-Health: A Case Study Afef JMAL MAÂLEJ and Moez KRICHEN EMG signals Analysis and PCA guided K-means Clustering for Myopathy Diagnosis Rim BARIOUL, Sameh FAKHFAKH GHRIBI and Olfa KANOUN A Bayesian network decision model for supporting the early diagnosis of Alzheimer's disease Ahmed MASMOUDI In silico and in vivo analysis reveals comprehensive insights into the date palm response to abiotic stress Zayneb CHAÂBENE, Imen REKIK, Franck VANDENBULCKE, Amine ELLEUCH and Hafedh MEJDOUB Whole Exome Sequencing in a Tunisian family with Psoriasis: Novel variations on PCNX gene R. AMMAR, N. BOUGACHA, S. MARRAKCHI, H. TURKI, A. SMAHI and H. AYADI Stochastic Function Norm Regularization for Neural Networks Amal RANNEN-TRIKI and Matthew B BLASCHKO OGDD v.1 (Olive Genetic Diversity Database): a microsatellite markers’ genotypes database of worldwide olive trees for cultivar identification and virgin olive oil traceability Rayda BEN AYED, Riadh BEN MARZOUG and Ahmed REBAI Locked Nucleic Acid Probe-Based Real-Time PCR for the quantification of Prorocentrum lima in seafood and aquatic environment samples Mohamed BARKALLAH and Slim ABDELKAFI

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Digital Research Center of Sfax Public Scientific and Technical Institution http://www.crns.rnrt.tn The Digital Research Center of Sfax, was created in July 2013. Its is a public institution whose mission is to conduct research and development activities in the field of information and communication technologies, and to foster innovation and technology transfer in this field by valorizing research results, resources, and expertise. It aims to beat the forefront of technology by conducting applied research focused on innovation. The staff is composed of high skilled senior researchers (university professors) and PhD students in advanced computing and telecommunication. They work to elaborate sophisticated and innovative solutions and to develop techniques and tools covering recent topics like smartgrid, e-health, smart transportation, e-government, etc.

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