Z e ro H our Exo so me s F ive H our Exo so me s

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Page 1. 0. 6. 12. 18. 24. 30. 36. 0. 10. 20. 30. 40. 50. O. C. R (p m o l/m in. /µ g p ro tein. ) Time (minutes). 0. 1. 2. 3. 4. 5. 6. 0. 10. 20. 30. 40. 50. EC. AR (m p. H.

30

5

24 18 12 6

4 3

ODS

2

ODR Control

1 0

0 10

20

30

40

0

50

10

20

Oligo

Oligo

FCCP

Time (minutes)

D.! 6

30

5

ECAR (mpH/min/µg protein)

C.! 36 OCR (pmol/min/µg protein)

30

40

50

40

50

Time (minutes)

FCCP

0

Five Hour Exosomes!

FCCP

Oligo

B.! 6 ECAR (mpH/min/µg protein)

A.! 36 OCR (pmol/min/µg protein)

Zero Hour Exosomes!

Oligo

FCCP

Supplementary Figure 5

24 18 12 6 0

4 3 2 1 0

0

10

20

30

Time (minutes)

40

50

0

10

20

30

Time (minutes)